Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites |
| |
引用本文: | 童光东,周大桥,贺劲松,李松林,彭立生.Effects of Shehuang Paste(麝黄膏) on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites[J].Chinese Journal of Integrated Traditional and Western Medicine,2006,12(4):255-261. |
| |
作者姓名: | 童光东 周大桥 贺劲松 李松林 彭立生 |
| |
作者单位: | Department of Hepatology, Shenzhen Hospital of TraditionalChinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Guangdong (518033) |
| |
基金项目: | Supported by State Administration of T0M (No. 02- 03LP40 ) |
| |
摘 要: | Objective: To explore the influence of Shehuang Paste (麝黄膏, SHP) to the hemodynamics, endotoxin, nitric oxide (NO), and endothelin-1 (ET-1) in patients with refractory cirrhotic ascites. Methods: Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups, 32 cases in the treatment group and 27 cases in the control group. The basic treatment was the same for both groups, including liver protecting medicines, diuretics and supportive drugs, but SHP navel sticking was applied for the treatment group additionally once a day. A course of one month of treatment was applied and the general efficacy on ascites was observed by the end of the therapeutic course. Before and after the treatment, examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content; colorimetry to measure plasma content of NO indirectly, radioimmunoassay to measure plasma ET-1 content; and color Doppler ultrasonography to measure the blood flow of portal vein and splenic vein. The relationship between the blood flow of portal vein and splenic vein and endotoxin, NO and ET-1 in the treatment group was analyzed as well. Results: The total effective rate on ascites was 84.4% in the treatment group, and 48. 1% in the control group, with significant difference shown between them (P〈0.01). In the treatment group the blood flow of portal vein and splenic vein, contents of endotoxin, NO and ET-1 all got significantly reduced after treatment ( P〈0.05 or P〈0.01); while these indexes in the control group were not significantly changed (P〉0.05). Moreover, it was found that in the treatment group, the blood flow of portal vein and splenic vein had a positive correlation to the levels of NO, ET-1, and endotoxin, either before or after treatment. Conclusion: Application of SHP navel sticking could clearly reduce the blood flow of portal vein and splenic vein, and lower the content of endotoxin, NO and ET-1. The blood flow of portal vein and splenic vein in the treatment group showed a positive correlation with the contents of endotoxin, NO and ET-1.
|
关 键 词: | 血液动力学 内毒素 硝石酸 血管活性 肝硬化 麝黄膏 |
收稿时间: | 2005-11-17 |
Effects of Shehuang Paste on hemodynamics, endotoxin, nitric oxide and endothelin-1 in patients with refractory cirrhotic ascites |
| |
Authors: | Guang-dong Tong Prof Da-qiao Zhou Jin-song He Song-lin Li and Li-sheng Peng |
| |
Abstract: | Objective To explore the influence of Shehuang Paste (麝黄膏, SHP) to the hemodynamics, endotoxin, nitric oxide (NO), and endothelin-1
(ET-1) in patients with refractory cirrhotic ascites.
Methods Fifty-nine cases of refractory cirrhotic ascites were randomly assigned to two groups, 32 cases in the treatment group and
27 cases in the control group. The basic treatment was the same for both groups, including liver protecting medicines, diuretics
and supportive drugs, but SHP navel sticking was applied for the treatment group additionally once a day. A course of one
month of treatment was applied and the general efficacy on ascites was observed by the end of the therapeutic course. Before
and after the treatment, examinations by limulus lysate chromogenic test was conducted to measure plasma endotoxin content;
colorimetry to measure plasma content of NO indirectly, radioimmunoassay to measure plasma ET-1 content; and color Doppler
ultrasonography to measure the blood flow of portal vein and splenic vein. The relationship between the blood flow of portal
vein and splenic vein and endotoxin, NO and ET-1 in the treatment group was analyzed as well.
Results The total effective rate on ascites was 84.4% in the treatment group, and 48.1% in the control group, with significant difference
shown between them (P<0.01). In the treatment group the blood flow of portal vein and splenic vein, contents of endotoxin, NO and ET-1 all got
significantly reduced after treatment (P<0.05 or P<0.01); while these indexes in the control group were not significantly changed (P>0.05). Moreover, it was found that in the treatment group, the blood flow of portal vein and splenic vein had a positive
correlation to the levels of NO, ET-1, and endotoxin, either before or after treatment.
Conclusion Application of SHP navel sticking could clearly reduce the blood flow of portal vein and splenic vein, and lower the content
of endotoxin, NO and ET-1. The blood flow of portal vein and splenic vein in the treatment group showed a positive correlation
with the contents of endotoxin, NO and ET-1.
Supported by State Administration of TCM (No. 02-03LP40) |
| |
Keywords: | liver cirrhosis refractory ascites vasoactive substance hemodynamics |
本文献已被 CNKI 维普 PubMed SpringerLink 等数据库收录! |
| 点击此处可从《Chinese Journal of Integrated Traditional and Western Medicine》浏览原始摘要信息 |
| 点击此处可从《Chinese Journal of Integrated Traditional and Western Medicine》下载免费的PDF全文 |
|