脑心通胶囊对局灶栓塞性脑缺血大鼠内皮素及降钙素基因相关肽含量的影响

目的：在大鼠局灶栓塞性脑缺血模型上观察脑心通胶囊对神经肽的影响，探讨其治疗脑缺血的可能机制。方法：采用FeCl3致大脑中动脉栓塞模型，应用放免法测定SD和自发性高血压大鼠(HSR)血浆、下丘脑中ET和CGRP含量。结果：脑心通可明显拮抗缺血24h以内的血浆CGRP降低及ET的升高，提高SHR脑缺血时脑组织CGRP含量。结论：脑心通主要对缺血早期ET及CGRP的异常变化有改善作用，而对缺血后期神经肽尚无明显影响，且以升高血浆及下丘脑中CGRP含量为主，对血浆ET的升高也有一定影响。

Effect of NXT on ET And CGRP in Rats With Focal Cerebral Ischemia

Objective:To investigate the effect of Buchang Naoxintong(NXT) on neuropeptide in focal stroke rats and elucidate the mechanisms.Methods:The content of endothelin(ET) and calcitonin gene related peptide(CGRP) in plasma and hypothalamus was measured via radioimmunoassay in both SD rats and spontaneous hypertension rats(SHR) with middle cerebral artery infarction.Results:Oral treatment with NXT counteracted both the decrease of CGRP and rise of NT in plasma during 24 hours after in farction and increased CGRP level in ischemic region in SHR.Conclusion:NXT increases CGRP level in both plasma and hypothalamus,and inhibits the increase of plasma NT in the early phase of stroke,no action on neuropeptide in the late phase of stroke was observed.