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Discovery of 2-Pyridylpyrimidines as the First Orally Bioavailable GPR39 Agonists |
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| Authors: | Stefan Peukert Richard Hughes Jill Nunez Guo He Zhao Yan Rishi Jain Luis Llamas Sarah Luchansky Adam Carlson Guiqing Liang Vidya Kunjathoor Mike Pietropaolo Jeffrey Shapiro Anja Castellana Xiaoping Wu Avirup Bose | |
| Affiliation: | NovartisInstitutes forBioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States | |
| Abstract: | ||
| Keywords: | GPR39 agonists, GPR39 receptor, Zn2+-sensing receptor, antidiabetic treatment, β -cellprotection, GLP-1 secretion, insulin secretion | |