Pentoxifylline and tocopherol protocol to treat medication-related osteonecrosis of the jaw: A systematic literature review |
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| Affiliation: | 1. Oral and Maxillofacial Surgeon at Bupa-Care Plus Assistencial Medicine, São Paulo, Brazil;2. General Surgeon at Private Hospital, Curitiba, Brazil;1. Assistant Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Okan University, Istanbul, Turkey;2. Assistant Professor, Department of Histology and Embryology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey;3. Assistant Professor and Head of Department, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Trakya University, Edirne, Turkey;4. Associated Professor and Head of Department, Department of Histology and Embryology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey;6. Professor, Private Practice, Oral and Maxillofacial Surgery, Istanbul, Turkey;1. Oral Surgery Dept, Floor 23, Guys Dental Hospital, London Bridge, London, SE1 9RT;2. Department of Informatics, King''s College London, Strand, London, WC2R 2LS;3. Department of Oral and Maxillofacial Surgery, Atrium 3, 3rd Floor, Bermondsey Wing, Guy''s Hospital, London, SE1 9RT;1. Department of Head and Neck Oncology, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France;2. Department of Radiology, Institut Gustave-Roussy, 14, rue Édouard Vaillant, 94800 Villejuif, France;3. IR4M, UMR 8081, CNRS, université Paris-Sud, université Paris-Saclay, 91400 Orsay, France;4. Department of Odontology, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France;5. Department of Radiotherapy, Gustave Roussy Institute, université Paris-Saclay, 14, rue Édouard Vaillant, 94800 Villejuif, France;1. Head and Neck Unit, Guy’s and St Thomas’ NHS Foundation Trust, London SE1 9RT;2. Maxillofacial Unit, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK;1. OMFS IMPATH Research Group, Department of Imaging & Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium;2. Department of Oral and Maxillofacial Surgery, University Hospitals Leuven, University of Leuven, Leuven, Belgium;3. Service de Stomatologie et Chirurgie Maxillo-faciale Centre Hospitalier et Universitaire Hôpital R. Salengro, 59037, Lille Cedex, France |
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| Abstract: | PurposeMedication-related osteonecrosis of the jaw (MRONJ) is a previously described debilitating condition in which patients experience progressive bone destruction in the maxilla and/or mandible after exposure to certain drugs. Clinical management of MRONJ remains controversial, with no established guidelines. The aim of our study was to conduct a literature review on the effectiveness of pentoxifylline (PTX) and tocopherol (PENTO protocol) on MRONJ.Study designA literature review was conducted, using two different scientific databases, to evaluate the effects of PTX and tocopherol on MRONJ.DiscussionPENTO protocol prescription to treat MRONJ was reported to be well tolerated, with minimal side-effects, and non-expensive when compared with other non-surgical treatment modalities. It was shown to relieve painful symptoms in all patients, and significant new bone formation was observed at final follow-up.ConclusionObservational and case-series studies have demonstrated that pentoxifylline and tocopherol are potentially useful in the non-surgical management of MRONJ. |
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| Keywords: | Medication-associated osteonecrosis of the jaw Bisphosphonate-associated osteonecrosis of the jaw Pentoxifylline Tocopherol |
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