Cognitive processing of cluster headache patients: evidence from event-related potentials |
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Authors: | Rongfei Wang Zhao Dong Xiaoyan Chen Ruozhuo Liu Mingjie Zhang Jinglong Wu Shengyuan Yu |
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Institution: | 1.Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, China;2.Medical school, Nankai University, Tianjin, China;3.Biomedical Engineering Laboratory, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-Naka, Okayama 700-8530, Japan |
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Abstract: | BackgroundThe peripheral and central origins of pain in cluster headache (CH) have been a matter of much debate. The development and application of functional imaging techniques have provided more evidence supporting the hypothesis that CH is not a disorder exclusively peripheral in origin, and in fact central regions might be more important. Event-related potentials confer advantages in the functional evaluation of the cortex, but few studies thus far have employed this method in cluster headache.MethodsSeventeen cluster patients (15 males; mean age = 35.4 years) and 15 age-matched healthy participants (13 males; mean age = 34.6 years) were recruited. A visual oddball paradigm was employed to analyze target processing using event-related potentials. We investigated the P3/P3d components in the experiment.ResultsP3/P3d amplitudes were decreased in CH patients (P3, 3.82 μV; P3d, 5.8 μV) compared with controls (P3, 7.28 μV; P3d, 8.95 μV), F(1,30) = 4.919, p < 0.05, η2 = 0.141 for P3 and F(1,30) = 8.514, p < 0.05, η2 = 0.221 for P3d, respectively). Moreover, the amplitudes of P3/P3d were no significantl difference in the side of pain as compared to contralateral one (p > 0.05).ConclusionsThese results provide evidence of dysfunction in the cognitive processing of CH patients, which may also contribute to the pathophysiology of CH. |
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Keywords: | Cluster headache ERPs P3/P3d Cognitive processing |
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