Impact of pretherapeutic neutrophil-to-lymphocyte ratio,serum albumin,body-mass index,and advanced lung cancer inflammation index on clinical outcome in sinonasal squamous cell carcinoma |
| |
| Affiliation: | 1. Department of Otolaryngology – Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut Street, 6th Floor, Philadelphia, PA 19107, USA;2. Department of Neurosurgery, Thomas Jefferson University, 909 Walnut Street, 2nd Floor, Philadelphia, PA 19107, USA;1. Department of Otolaryngology/Head and Neck Surgery, 170 Manning Drive, CB 7070, Chapel Hill, NC 27599, USA;2. Department of Neurosurgery, 170 Manning Drive, CB 7060, Chapel Hill, NC 27599, USA;1. Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology- Head and Neck Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia;2. Rhinology and Endoscopic Skull Base Program, Department of Otolaryngology, Miller School of Medicine, University of Miami, Clinical Research Building, 5th Floor, 1120 Northwest 14th Street, Miami, FL 33136, USA;1. Radioneurosurgery Unit, National Institute of Neurology and Neurosurgery, Mexico City, Mexico;2. Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA;3. Department of Otorhinolaryngology-Head & Neck Surgery, McGovern Medical School, The University of Texas Health Sciences Center at Houston, Houston, Texas, USA;4. Unit of Functional Neurosurgery, Stereotaxy and Radiosurgery, Mexico General Hospital, Mexico City, Mexico;5. Mischer Neuroscience Institute, Memorial Hermann Hospital, Houston, Texas, USA;1. Department of Otolaryngology, Weill Cornell Medical College, 1320 York Avenue, New York, NY 10021, USA;2. Hofstra North Shore-LIJ School of Medicine, 500 Hofstra University, Hempstead, NY 11549, USA;3. The Center for Head & Neck Oncology, New York Head & Neck Institute, North Shore-LIJ Cancer Institute, 130 East 77th Street, Black Hall 10th Floor, New York, NY 10075, USA;4. The Center for Thyroid & Parathyroid Surgery, New York Head and Neck Institute, New York, NY, USA |
| |
| Abstract: | BackgroundSquamous cell carcinoma of the nasal cavity and paranasal sinuses is a rare and aggressive cancer entity with poor survival rates. Data on this group of head and neck tumors are scarce. Inflammation and cachexia-based markers and their impact on clinical outcome have been studied in several cancer groups. The aim of this study was to evaluate their prognostic potential in sinonasal squamous cell carcinoma.Patients and methodsThis retrospective analysis included all patients treated for sinonasal squamous cell carcinoma at a tertiary referral center between 2002 and 2015. Patients were divided into groups with low and high pretherapeutic values based on the values of serum albumin (ALB, median 41.6 g/l), neutrophil-to-lymphocyte ratio (NLR, median 3.5), body-mass index (BMI, median 24.7), or advanced lung cancer inflammation index (ALI, median 29.5). Main outcome measures were overall survival (OS) and disease-free survival (DFS). Statistical analysis included calculation of survival differences using log-rank tests, hazard ratios (HR), and respective 95% confidence intervals (CI).Results41 patients were included. Low ALB values did not influence OS (median OS not reached in both groups; p = 0.59, HR = 0.75, CI = 0.3–2.1) or DFS (median DFS 0.9 years vs 2.2 years; p = 0.6, HR = 0.8, CI = 0.4–1.8). High NLR was significantly associated with worse OS rates (median OS not reached vs 1.7 years, p = 0.02, HR = 3.4, CI = 1.0–108) but with no influence on DFS (median DFS 3.1 years vs 0.8 years; p = 0.15, HR = 1.8, CI = 0.8–4.2). Similar results were observed for patients with low ALI (median OS 1.7 years vs not reached; p = 0.03, HR = 0.3, CI = 0.1–0.9 and median DFS 0.8 years vs 2.2 years; p = 0.58, HR = 0.8, CI = 0.3–1.8). BMI was the strongest prognosticator in our study. Low pretherapeutic BMI was linked to significantly worse OS (median OS 1.4 years vs not reached; p = 0.003, HR = 0.2, CI = 0.0–0.6) and DFS (median DFS 0.8 years vs not reached; p = 0.02, HR = 0.4, CI = 0.2–0.8). In multivariate analysis BMI was revealed as an independent marker for OS (p = 0.015). No marker reached the level of significance in regard to DFS in multivariate analysis.ConclusionPretherapeutic BMI had a superior prognostic value in patients with sinonasal squamous cell carcinoma in comparison with other tested variables. BMI may be a simple tool for estimating clinical outcome in SNSCC. However, larger studies are necessary to validate our results. |
| |
| Keywords: | Sinonasal carcinoma Advanced lung cancer inflammation index Body mass index Pretherapeutic markers Inflammation markers |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
