Differential modulation by glucocorticoids of alternative complement protein secretion in cells of the monocyte/macrophage lineage. |
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Authors: | C Lemercier N Julen M Coulpier H Dauchel D Ozanne M Fontaine J Ripoche |
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Institution: | INSERM Unité 78, Bois-Guillaume, France. |
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Abstract: | The effect of the synthetic glucocorticoid dexamethasone (DXM) on the secretion by human monocytes of alternative complement proteins C3, factor B and factor H was investigated. Results indicated that DXM modulates this secretion in a direction which would be consistent with its anti-inflammatory properties. DXM, at therapeutic concentrations, had a suppressive effect on C3 and factor B secretion and a stimulatory effect on factor H secretion by monocytes. This differential modulation on C3, factor B and factor H secretion was similar in mature macrophages. Together with previous studies showing that DXM had a suppressive effect on C3 and factor B secretion and a stimulatory effect on factor H secretion by human endothelial cells, our results indicate that DXM appears to have the general property of regulating local production of complement components so as to control complement activation. |
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