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| 龙葵药材中澳洲茄碱、澳洲茄边碱的含量测定 | |
| 引用本文： | 李明慧,丁岗,孟兆青,蔡静,刘景晶. 龙葵药材中澳洲茄碱、澳洲茄边碱的含量测定[J]. 中国天然药物, 2007, 5(5): 360-362 |
| 作者姓名： | 李明慧 丁岗 孟兆青 蔡静 刘景晶 |
| 作者单位： | 1. 中国药科大学生命科学与技术学院,南京,210009;江苏省中药质量控制工程技术研究中心,南京,211100 2. 江苏省中药质量控制工程技术研究中心,南京,211100 3. 中国药科大学生命科学与技术学院,南京,210009 |
| 摘 要： | 目的:寻找可以作为评价龙葵药材质量的指标成分,提高龙葵药材的质量标准。方法:采用柱层析方法分离化学成分,应用光谱法进行结构鉴定,用高效液相色谱法测定其在龙葵药材不同部位的含量。结果:从龙葵药材中分离并鉴定了2个含量较高的甾体类生物碱苷澳洲茄碱(solasonine)和澳洲茄边碱(solamar-gine);建立了龙葵药材中澳洲茄碱、澳洲茄边碱的HPLC含量测定方法。结论:这两种生物碱在龙葵药材中含量较高,可用于龙葵药材的质量控制。 |
| 关 键 词： | 龙葵 澳洲茄碱 澳洲茄边碱 |
| 文章编号： | 1672-3651（2007）05-0360-03 |
| 修稿时间： | 2007-04-16 |
Content Determination of Solasonine and Solamargine in Solanum nigrum |
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| LI Ming-Hui,DING Gang,MENG Zhao-Qing,CAI Jing,LIU Jing-Jing. Content Determination of Solasonine and Solamargine in Solanum nigrum[J]. Chinese JOurnal of Natural Medicines, 2007, 5(5): 360-362 | |
| Authors: | LI Ming-Hui DING Gang MENG Zhao-Qing CAI Jing LIU Jing-Jing |
| Abstract: | AIM:To find the criterion constituents in Solanum nigrum,which can be used to improve the quality of Solanum nigrum. METHODS:Chemical constituents were isolated and purified by chromatographic methods. Structural identification was based on chemical and spectroscopic evidence. HPLC was used for quantitative analysis of Solanum nigrum. RESULTS:Two glycoalkaloids were purified and identified as solasonine and solamargine. An HPLC method for the determination of Solasonine and Solamargine in Solanum nigrum was established. CONCLUSION:Solasonine and solamargine were the main bioactive constituents of Solanum nigrum,which can be used to control the quality of Solanum nigrum. |
| Keywords: | HPLC |
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