| 山东地区汉族大疱性类天疱疮与HLA-DR,DQB1基因的相关性研究 |
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| 引用本文： | 周淑华,王秀敏,韩兆东,高昱,张玉杰,杨磊.山东地区汉族大疱性类天疱疮与HLA-DR,DQB1基因的相关性研究[J].中国皮肤性病学杂志,2007,21(2):72-74. |
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| 作者姓名： | 周淑华 王秀敏 韩兆东 高昱 张玉杰 杨磊 |
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| 作者单位： | 1. 山东省立医院皮肤科,山东,济南,250021
2. 山东省滨州医学院附属医院皮肤科,山东,滨州,256603 |
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| 摘 要： | 目的探讨HLA-DR,DQB1位点基因在大疱性类天疱疮(BP)易感性中的作用。方法用序列特异性引物-聚合酶链反应(PCR-SSP)方法,对49例BP患者及70例正常对照者进行了HLA-DR,DQB1等位基因的分型,并分析了上述基因在两组中的分布。结果与正常对照组比较,BP患者组DRB1*10基因频率明显增高(校正P值<0.05);DRB1*04-DQB1*0302连锁体频率、DRB1*10-DQB1*0501连锁体频率在BP组均显著高于对照组;DRB1*04在黏膜损害及大剂量皮质类固醇激素用量组显著增高。结论HLA-DR10(DRB1*10)可能是中国汉族BP的易感基因。DRB1*04-DQB1*0302连锁体、DRB1*10-DQB1*0501连锁体可能为汉族BP的易感连锁体。
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| 关 键 词： | 类天疱疮 大疱性 聚合酶链反应 HLA-DRB1 HLA-DQB1 |
| 文章编号： | 1001-7089（2007）02-0072-03 |
| 收稿时间： | 2006-07-19 |
| 修稿时间： | 2006-07-192006-10-18 |
Study on the Association between HLA-DRB1 Genes and Bullous Pemphigoid in Shandong Han Chinese |
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| ZHOU Shu-hua,WANG Xiu-min, HAN Zhao-dong,et al.Study on the Association between HLA-DRB1 Genes and Bullous Pemphigoid in Shandong Han Chinese[J].The Chinese Journal of Dermatovenereology,2007,21(2):72-74. |
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| Authors: | ZHOU Shu-hua WANG Xiu-min HAN Zhao-dong |
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| Institution: | Binzhou medical College Hospital, Binzhou, shandong 256603, China |
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| Abstract: | Objective To investigate the predisposing role of HLA-DRB1,DQB1genes in bullous pemphoid (BP) Methods We used polymerase chain reaction-specific sequence primers method to type HLA-DRB1,DQB1 subregion in the patients with BP of Han nationality from shandong province and matched that with the control subjects. Results The results demonstrated that DRB1*10 gene frequencies were significantly higher in BP than those in controls(P<0.05 ).Conclusion The results suggested that HLADRB1*10 might be susceptible gene in north Chinese BP.The combination of HLA-DRB1*04,DQB1*0302 and HLA-DRB1*10,DQB1*0501 forms a putative susceptible haplotypes |
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| Keywords: | HLA-DRB1 HLA-DQB1 |
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