Immunoprotective Effects of Prolactin during Stress-Induced Immune Dysfunction |
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| Authors: | E. E. Fomicheva E. A. Nemirovich-Danchenko E. A. Korneva |
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| Affiliation: | Department of General Pathology and Pathophysiology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia. fomivhev@AG8070.spb.edu |
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| Abstract: | We showed for the first time that prolactin stimulates the synthesis and release of immunomodulating cytokines and lymphocyte-activating factors (e.g., interleukin-1) by peritoneal macrophages. Prolactin abolished the stress-induced inhibition of proliferation of peripheral blood lymphocytes and increased cell sensitivity to regulatory effects of interleukin-1 in the reaction of lymphocyte blast transformation. These data illustrate the mechanism of immunoprotective activity of prolactin during stress. |
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| Keywords: | prolactin stress lymphocyte-activating factors lymphocyte proliferation |
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