Specific mu 2 opioid isoreceptor regulation of nigrostriatal neurons: in vivo evidence with naloxonazine |
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| Authors: | P L Wood G W Pasternak |
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| Institution: | 1. Douglas Hospital Research Centre, 6875 LaSalle Blvd. Verdun, Qué. H4H 1R3, Canada;2. Cotzias Lab. of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, Dept. of Neurology, Cornell University Medical College, New York, NY 10021, U.S.A. |
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| Abstract: | The irreversible mu 1 opiate antagonist, naloxonazine, totally blocked the analgesic actions (tail-flick assay) of morphine (8 mg/kg) in the rat. However, this treatment was without effect on the morphine-dependent (4 mg/kg) increases in striatal dopamine metabolism. These data support our previous studies which have suggested mu 2 and delta opioid receptor regulation of the rat nigrostriatal pathway. |
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| Keywords: | μ opioid isoreceptors naloxonazine dopamine metabolism |
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