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血管内皮生长因子在胃癌中的表达及其与血管生成和细胞增殖的关系
引用本文:吴泰璜,申泮远,苏忠学,穆庆岭.血管内皮生长因子在胃癌中的表达及其与血管生成和细胞增殖的关系[J].中华实验外科杂志,2000,17(1):42-43.
作者姓名:吴泰璜  申泮远  苏忠学  穆庆岭
作者单位:250021,济南,山东省立医院普通外科
摘    要:目的 探讨血管内皮生长因子在胃癌中的表达及其与血管生成、细胞增殖关系。方法 应用免疫组织化学方法检测50例胃癌标本的VEGF表达情况。结果 VEGF表达与胃癌转移及术后早期复发有关。淋巴结转移组和无转移组VEGF阳性率分别为70.59%和31.25%,两组差异有极显著性。肿瘤浸润达浆腊和未达浆膜组VEGP阳性率分别为65.80%及33.33%,差异有显著性。结论检测VEGF表达可作为胃癌的预后指标

关 键 词:胃肿瘤  血管生成因子  细胞增殖  VEGF
修稿时间:1999-03-16

The expression of vascular endothelial growth factor and its relationship with neovascularization and tumor cell proliferation in gastric cancer
WU Taihuang,SHEN Panyuan,SU Zhongxue,et al..The expression of vascular endothelial growth factor and its relationship with neovascularization and tumor cell proliferation in gastric cancer[J].Chinese Journal of Experimental Surgery,2000,17(1):42-43.
Authors:WU Taihuang  SHEN Panyuan  SU Zhongxue  
Institution:WU Taihuang,SHEN Panyuan,SU Zhongxue,et al. Department of General Surgery,Shandong Provincial Hospital,Jinan 250021,China
Abstract:Objective\ To investigate the expression of vascular endothelial growth factor (VEGF) in gastric carcinomas and its relationship with angiogenesis and tumor cell proliferation.Methods\ The expression of VEGF was detected by immunohistochemistry assay.Results\ The expression of VEGF was related with metastasis of gastric carcinomas and early relapse after operation. The positive rate in lymph node metastasis group and non metastasis group was 70.59 % and 31.25 % respectively with the difference being significant ( P <0.01). The positive rate was 65.80 % in tumors that invaded or penetrated the serosa and 33.33 % in tumors that did not invaded the serosa with the difference being significant ( P <0.05). Conclusion\ Examination of VEGF expression can help to select the patients who need chemotherapy and radiotherapy, and may be as an indicator of prognosis.
Keywords:Stomach neoplasms  Vascular endothelial growth factor  Angiogenesis factor  
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