注射用头孢米诺钠输液中的配伍稳定性研究

目的：考察输液中注射用头孢米诺钠与0.9%氯化钠注射液和5%葡萄糖注射液配伍时的稳定性。方法：以0.9%氯化钠注射液和5%葡萄糖注射液分别配制头孢米诺钠溶液,分别于配制后的不同时间点以HPLC法测定头孢米诺钠及有关物质的含量,观察溶液的物理状态和pH值变化。结果：头孢米诺钠在0.10～2.0mg/ml浓度范围内与峰面积呈良好线性关系,在室温（25℃）条件下,4 h内主成分及有关物质含量均符合标准规定。结论：注射用头孢米诺钠与0.9%氯化钠注射液和5%葡萄糖注射液配伍在观察的4 h时间内质量稳定可靠。

Research on the compatible stability of cefminox sodium for injection during transfusion

Objective： To investigate the Compatible Stability of cefminox sodium for injection during transfusion with 0. 9% sodium chloride injection and 5% glucose injection. Methods： Cefminox sodium injection was prepared by 0. 9% sodium chloride injection and 5% glucose injection. The contents of cefminox sodium and related substance were detected by HPLC different time after preparation. Meanwhile, the physical condition and pH value were also observed. Results： The linear relation of concentration range 0. 10 -0. 20 and peak area was favourahle. Under 25℃, the contents of cefminox sodium and related substance were all accord with the standard code of Chinese pharmacopoeia in 4 h. Conclusion： The compatibility of 0. 9% sodium chloride injection and 5% glucose injection with cefminox sodium for injection is steady.