阴黄型与阳黄型肝炎大鼠Survivin蛋白表达的差异 |
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引用本文: | 林春颖,蔡沛芳,黄凤婷,卢雪明. 阴黄型与阳黄型肝炎大鼠Survivin蛋白表达的差异[J]. 中国民族民间医药杂志, 2012, 0(3): 48-49 |
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作者姓名: | 林春颖 蔡沛芳 黄凤婷 卢雪明 |
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作者单位: | [1]广州中医药大学第三附属医院,广东广州510360 [2]中山大学附属第六医院,广东广州510655 |
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基金项目: | 广州中医药大学中医药科研创新基金资助项目“阴黄、阳黄证在慢性重型乙型肝炎的蛋白质组差异表达研究”,(编号:08CX86) |
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摘 要: | 目的:观察阴黄型和阳黄型肝炎大鼠在Survivin蛋白上表达的差异。方法:将Wistar大鼠随机分为A、B、C三组,选A组大鼠,将其置于湿热造模环境下,每天喂1:1的5%葡糖糖和猪油脂的混合液20ml/kg/2次/日灌胃;取B组大鼠,给予2kg/L大黄煎剂按照50ml/kg剂量每天灌胃2次;C组为对照组,给予等量的0.9%的氯化钠;并于第15天后给予A、B组大鼠5%异硫氰酸苯酯20ml/kg体重溶于色拉油中灌胃,每天1次;48小时后采样,测定比较各组胆红素及胆汁酸及survivin蛋白的变化情况。结果:相比对照组,阴黄型和阳黄型大鼠的胆红素和胆汁酸明显升高,survivin有显著表达,且阴黄组明显大于阳黄组。结论:Survivin蛋白在阴黄型和阳黄型肝炎大鼠中表达有明显差异。
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关 键 词: | 肝炎 阴黄 阳黄 Survivin蛋白 |
The Study of differences on the Expression of Survivin Gene in rats |
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Abstract: | Ojective: To evaluate the differences on the expression of Survivin gene in rats. Methods: Rats were randomly divided into A, B, C groups, Group A were administered with mixture of (1:1 ) 0. 5% glucose: fat by 20ml/kg/twice/day, group B with Dahuang decotion by 40ml/kg/once/dayand group C with the same saline oroally, after 15 days to compared the expresstion of survivin protion. Results: To comoared group, the survivin expression of Yanghuang is high and Yinhuang is higher. Conclusions: The expression of Survivin is diferent btween Yinhuang and Yanghuang rats. |
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Keywords: | hiptatis Yinhuang Yanghuang Survivin |
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