| 两种氢溴酸高乌甲素经皮给药制剂药效学研究 |
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| 引用本文： | 邱永锋,沙先谊,方晓玲. 两种氢溴酸高乌甲素经皮给药制剂药效学研究[J]. 中国民族民间医药杂志, 2012, 0(6): 38-39 |
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| 作者姓名： | 邱永锋 沙先谊 方晓玲 |
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| 作者单位： | 复旦大学药学院药剂学教研室,上海200032 |
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| 摘 要： | 目的：研究氢溴酸高乌甲素两种经皮给药制剂的镇痛效果。方法：通过制备两种制剂：微乳、凝胶。采用小鼠热板法疼痛试验和小鼠扭体法疼痛试验测定氢溴酸高乌甲素两种透皮制剂的镇痛效果。结果：发现两种制剂给药组镇痛效果优于空白组，氢溴酸高乌甲素微乳的镇痛效果优于氢溴酸高乌甲素凝胶制剂，对扭体法和热板法所致的小鼠疼痛有明显的镇痛作用（P〈0．01）。结论：说明氢溴酸高乌甲素凝胶和微乳均有镇痛作用，微乳镇痛效果优于凝胶。
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| 关 键 词： | 氢溴酸高乌甲素 微乳 凝胶 镇痛，热板法，扭体法 |
Research of two kinds of lappaconitine hydrobromide transdermal preparation pharmacodynamics |
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| Affiliation: | Qiu yong - feng, Sha xian - yi, Fang xiao - ling Department of Pharmaceutics, Fudan University, Shanghai 200322 |
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| Abstract: | Objectiae： To study the Lappaconitine hydrobromide two preparation for percutaneous administration of analgesic effect. Method： Prepare two formulations of Lappaconitine hydrobromide ： microemulsion, gel. And determine the analgesic effect of two lappaconitine hydrobromide transdermal preparation by the mouse hot plate method and mouse writhing method Results： The analgesic effect of two preparations is better than that of the blank, the analgesic effect of Lappaconitine hydrobromide microemulsion is better than that of gel, the writhing method and hot plate has significant analgesic effect （P 〈0. 01 ）. Conclusion： Preparation of lap- Daconitine tel and microemulsion have analgesic effect, analgesic effect is better than that of microemulsion gel. |
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| Keywords: | Lappaconitine hydrobromide microemulsion gel analgesia, hot plate, writhing method |
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