Comparison of effects of estriol on bone mineral density of vertebrae between elderly and postmenopausal women |
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Authors: | Akira Nishibe Shigeto Morimoto Kenji Hirota Masumi Shimizu Hiroshi Okuma Keisuke Fukuo Osamu Yasuda Toshio Onishi Toshio Ogihara |
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Institution: | (1) Departments of Geriatric Medicine and,;(2) Obstetrics, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, JP;(3) Department of Medicine, Hanwa-Senboku Hospital, 3176 Fukaikitamachi, Sakai, Osaka 593, Japan, JP |
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Abstract: | To compare the efficacy of estriol (E3) for postmenopausal and senile osteoporosis, we administered orally 1 g/day calcium lactate alone (control groups) or with
2 mg/day estriol (E3 groups) to 20 postmenopausal women aged 50–65 years and 29 elderly women aged 70–84 years, and determined their bone mineral
density (BMD) of the lumbar vertebrae AP scan by dual-energy X-ray absorptiometory. Of 41 subjects who completed 10 months
of treatment, 8 postmenopausal women and 12 elderly women in the E3 groups showed a significant (P < .05) increase in BMD, 5.59% ± 4.79% and 3.83% ± 7.90% of the respective basal values, while 10 postmenopausal women and
11 elderly women in the control groups showed a decrease in BMD, −4.02% ± 7.00% and −3.26% ± 4.60% of the respective basal
values, after 10 months. On the other hand, genital bleeding as a side effect of E3 occurred in 6 elderly subjects at this dose. Moreover, decrease in serum level of corrected calcium was seen only in the
elderly women receiving E3. Although a lower dosage of E3 may be recommended for elderly subjects, these observations suggest, first, that hormone replacement therapy with E3 has efficacy for involutional osteoporosis, and, second, that the bones in elderly women also maintain responsiveness to
E3.
Received: May 19, 1997 / Accepted: July 7, 1997 |
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Keywords: | : estriol elderly women postmenopausal women osteoporosis hormone replacement therapy |
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