再生障碍性贫血患者血清sFas、sFasL测定及临床意义

目的: 探讨血清可溶性Fas (soluble Fas,sFas)和可溶性Fas配体(soluble Fas Ligand,sFasL)在再生障碍性贫血(aplastic anemia,AA)患者血清中的变化及临床意义。方法: 采用酶联免疫吸附双抗体夹心法检测30例再生障碍性贫血患者血清sFas、sFasL水平。结果: 再生障碍性贫血患者血清sFas水平显著低于正常对照(P<0.01);重型再生障碍性贫血患者血清sFas水平明显低于慢性再生障碍性贫血(P<0.05);血清sFas浓度与再生障碍性贫血患者临床分型和疗效相关。血清sFasL水平在再生障碍性贫血患者和正常对照血清中含量差异无显著性(P>0.05)。结论: AA患者血清sFas水平降低,可作为反映AA病情严重程度和疗效观察的有效指标之一。

The detection of serum Fas and Fas Ligand in patients with aplastic anemia and its clinical significance

Objective:To study the variation of soluble serum Fas and soluble Fas Ligand in patients with aplastic anemia.Methods:The level of sFas and sFas Ligand in the serum of 30 patients with aplastic anemia were measured by enzyme-linked immunosorbent assay(ELISA).Results:The level of sFas in the patients with aplastic anemia(AA) was apparently lower than that of normal controls(P<0.01),and the level of sFas in the patients with severe aplastic anemia(SAA)was much lower than that of patients with chronic aplastic anemia(CAA)(P<0.05);The level of sFas in AA patients was related to the clinical types and curative effects.The levels of sFas ligand in AA patients and controls had no difference.Conclusions:The level of sFas in AA patients is below the normal.Detection of the level of sFas in AA patients is an effective indication of the condition of the patients.