3种抗组胺药抗组胺及抗花生四烯酸作用的比较研究

目的:比较咪唑斯汀、氯雷他定、西替利嗪3种抗组胺药的抗组胺及抗花生四烯酸的作用。方法:给大鼠左、右爪分别皮下注射花生四烯酸(1.0g/L,0.1mL)和组胺(10g/L,0.1mL)构建鼠爪水肿炎性模型。在注射花生四烯酸和组胺2h前分别给予咪唑斯汀、氯雷他定、西替利嗪(0.6mg/kg)灌胃,注射后应用体积测量仪分别测定给药后鼠爪体积在不同时间点的变化。结果:咪唑斯汀可抑制花生四烯酸所致的鼠爪水肿(P<0.05),西替利嗪、氯雷他定对其无明显抑制作用;咪唑斯汀对组胺所致的鼠爪水肿有抑制作用(P<0.05),抑制作用强于氯雷他定组,但与西替利嗪组比较无统计学差异(P>0.05)。结论:咪唑斯汀具有抗组胺和抗花生四烯酸的作用,且其抗组胺作用强于氯雷他定;与氯雷他定、西替利嗪相比,咪唑斯汀表现出其独特的抗花生四烯酸的作用。

Comparison study on anti-histamine and anti-arachidonic activity of three histamine antagonists

Objective:To evaluate the anti-histamine and anti-arachidonic acid potency of mizolastine,loratadine and cetirizine.Methods:The inflammatory edema reaction of rat paw was induced by a subcutaneous injection of arachidonic acid(1.0 g/L,0.1 mL)and histamine(10 g/L,0.1 mL)respectively.Mizolastine(0.6 mg/kg),loratadine(0.6 mg/kg)or cetirizine(0.6 mg/kg)were given orally 2 hours before the injection.The swelling volumes of rat paw were measured plethysmographically and compared at the different time points after the administrations,respectively.Results:Mizolastine inhibited arachidonic acid induced paw edema reaction significantly(P < 0.05).No significant inhibitory effects were found after administration of loratadine and cetirizine.Mizolastine inhibited histamine induced paw edema reaction significantly(P < 0.05),and its effects was stronger than those of loratadine,but had no significant difference compared with cetirizine(P > 0.05).Conclusions:Mizolastine shows a dual potency in anti-histamine and anti-arachidonic acid activities.It exerts a higher anti-histamine effect than loratadine.Compared with loratadine and cetirizine,Mizolastine displays unique anti-arachidonic acid activity.