Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26. |
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Authors: | M A Pericak-Vance K J Nunes E Whisenant D B Loeb K W Small J M Stajich J B Rimmler L H Yamaoka D I Smith H A Drabkin |
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Institution: | M A Pericak-Vance, K J Nunes, E Whisenant, D B Loeb, K W Small, J M Stajich, J B Rimmler, L H Yamaoka, D I Smith, H A Drabkin, et al. |
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Abstract: | A genetic map of highly polymorphic microsatellite markers spanning the von Hippel-Lindau region (VHL) of 3p25 was constructed using the CEPH reference pedigrees. A greater than 1000:1 odds map of pter-D3S1038-RAF1-D3S651-D3S656-D3S110- D3S1255-cen was found. Genotyping of six multigenerational VHL families showed the region surrounding the D3S1038 marker to be the most likely location for the VHL gene with a peak location score of 10.04 with VHL completely linked to D3S1038. These data provide an initial high resolution genetic map of this region; D3S1038 appears to be a highly polymorphic marker that should prove useful in the future for presymptomatic diagnosis. |
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