枳术宽中胶囊对抑郁动物模型的抗抑郁作用研究

目的 研究枳术宽中胶囊对动物抑郁模型的抗抑郁作用.方法 采用小鼠强迫游泳试验、悬尾试验、利血平拮抗、5-羟色胺酸(5-HTP)增强,大鼠慢性应激等抑郁模型,观察枳术宽中胶囊的抗抑郁作用.结果 枳术宽中胶囊1.106 g/kg减少了悬尾小鼠和强迫游泳小鼠的不动时间.枳术宽中胶囊各剂量均能拮抗利血平腹腔注射后1h所致的小鼠降温作用.枳术宽中胶囊1.106 g/kg增加了小鼠甩头次数.对慢性应激大鼠,枳术宽中胶囊0.774 g/kg增加了水平运动,0.774g/kg、0.387 g/kg增加了大鼠蔗糖水偏嗜度,降低了血清皮质酮含量.枳术宽中胶囊0.774 g/kg增加了5HT1A受体表达.结论 枳术宽中胶囊可以改善动物抑郁行为,具有抗抑郁作用,其机制可能与改善5-羟色胺(5-HT)能神经元传递、抑制应激引起的皮质激素分泌有关.

Antidepressant effect of Zhizhukuanzhong Capsules on animal model of depression

Objective To study the antidepressant effect of Zhizhukuanzhong Capsules on animal model of depression. Methods The tests of forced swimming, tail suspension, antagonism of reserpine and accentuation of 5-HTP in mice and chronic stress in rats were carried out to observe the antidepressant effect of Zhizhukuanzhong Capsules. Results Zhizhukuanzhong Capsules (1. 106 g/kg) shortened the dead time of tail suspension and forced swimming in mice. Zhizhukuanzhong Capsules in different doses resisted the descent of body temperature induced by the injection of reserpine after one hour, while in dose of 1.106 g/kg increased the frequency of head flick in mice. In chronic stress rats the horizontal movement was improved by Zhizhukuanzhong Capsules in dose of 0.774 g/kg, glycotropic degree was increased in dose of 0.774 g/kg or 0. 387 g/kg, serum content of corticosterone was reduced, and the expression of 5HT1A receptor was promoted. Conclusion Zhizhukuanzhong Capsules has antidepressant effect and can relieve the depressant behaviors of animals. The mechanism may be related to that it improves 5HT neuron transmission and inhibits the secretion of adrenocortical hormones.