| 核纤层蛋白Lamin A的结构及功能和代谢特征 |
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| 引用本文： | 马延超,许寿生,周越,王瑞元.核纤层蛋白Lamin A的结构及功能和代谢特征[J].中国组织工程研究与临床康复,2009,13(46). |
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| 作者姓名： | 马延超 许寿生 周越 王瑞元 |
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| 作者单位： | 1. 洛阳师范学院体育学院,河南省洛阳市,471022;北京体育大学,北京市,100084
2. 北京体育大学,北京市,100084 |
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| 基金项目： | 国家自然科学基金课题(30570896) a grant from the National Natural Science Foundation of China. No.30570896 |
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| 摘 要： | Lamin A是细胞核内重要的骨架蛋白,对维持细胞的形态结构具有重要作用.文章综述了LMNA基因在染色体的位置,lamin A蛋白质的形态、结构;LMNA基因不同位点的突变和缺失时机体产生的不同疾病:核纤层蛋白lamin A参与成肌细胞的分化作用功能:Caspase-6可促进核纤层蛋白lamin A的裂解以及NFAT5可能促进lamin A的表达等调节作用.
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| 关 键 词： | 功能 代谢 |
Structure,function,and metabolism of Lamin A |
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| Ma Yan-chao,Xu Shou-sheng,Zhou Yue,Wang Rui-yuan.Structure,function,and metabolism of Lamin A[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2009,13(46). |
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| Authors: | Ma Yan-chao Xu Shou-sheng Zhou Yue Wang Rui-yuan |
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| Abstract: | Lamin A,which is an important skeleton protein in the cell nucleus,can play an important role in maintaining the morphological structures of the cells.This article summarizes the location of LMNA gene in the chromosome,the shape and the structum of lamin A protein;the different diseases of the body which result from the mutations and deletions of LMNA gene in different sites;the differentiation functions of myoblast in which lamin A is involved:degradation of lamin A that may be promoted by Caspase-6;theexpression of lamin Athatmay bepromoted by NFAT5. |
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| Keywords: | lamin A |
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