| 缬草单萜氧化物对单个兔心室肌细胞钠通道的影响 |
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| 引用本文： | 黄峥嵘,唐其柱,史锡腾,王腾,沈涤非. 缬草单萜氧化物对单个兔心室肌细胞钠通道的影响[J]. 中国心脏起搏与心电生理杂志, 2004, 18(3): 212-214 |
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| 作者姓名： | 黄峥嵘 唐其柱 史锡腾 王腾 沈涤非 |
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| 作者单位： | 武汉大学人民医院心内科,湖北武汉,430060 |
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| 摘 要： | 利用全细胞膜片钳记录技术研究缬草单萜氧化物 (VMO)对兔单个心室肌细胞钠离子电流 (INa)的影响。结果 :30 μg/L和 6 0 μg/L的VMO使兔心室肌细胞INa峰值 (INamax)从 5 3.4 7± 5 .1 3pA/pF分别降至 4 0 .2 5± 4 .1 8pA/pF和 30 .89± 2 .95pA/pF(n =8,P <0 .0 5和P <0 .0 1 ) ,抑制率分别为 2 4 .7%和 4 1 .9% ;VMO使INa的电流 电压曲线上移 ,但不改变其激活电位、电位峰值和反转电位 ;VMO还减慢钠通道灭活后的恢复过程。结论 :VMO对INa具有浓度依赖性阻滞作用 ,这可能是其抗心律失常的重要机制之一。
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| 关 键 词： | 心血管病学 缬草单萜氧化物 膜片钳 钠通道 心室肌细胞 兔 |
| 文章编号： | 1007-2659(2004)03-0212-03 |
| 修稿时间： | 2003-09-22 |
Effect of Valeriana Officinalis L Extract on Sodium Current in Rabbit Ventricular Myocytes |
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| HUANG Zheng rong,TANG Qi zhu,SHI Xi teng,et al.. Effect of Valeriana Officinalis L Extract on Sodium Current in Rabbit Ventricular Myocytes[J]. Chinese Journal of Cardiac Pacing and Electrophysiology, 2004, 18(3): 212-214 |
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| Authors: | HUANG Zheng rong TANG Qi zhu SHI Xi teng et al. |
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| Affiliation: | HUANG Zheng rong,TANG Qi zhu,SHI Xi teng,et al. Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,China |
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| Abstract: | Whole cell patch clamp technique was used to investigate the effect of valeriana officinalis L extract(VMO) on sodium current(I Na ) in rabbit ventricular myocytes . Resultes : VMO at 30,60 μg/L decreased peak I Na (I Namax ) from 53.47±5.13 pA/pF to 40.25±4.18 pA/pF and 30.89±2.95 pA/pF( n=8,P<0.05 and P<0.01).VMO upshifted the I Na I V curves but didn′t change their active, peak and reverse potentials; VMO at 60 μg/L turned the steady state inactivation curve to right. Conclusion: VMO blocks I Na in a concentration dependent manner and probably inhibits I Na in its inactive state, which may contribute to its antiarrhythmic effect. |
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| Keywords: | Cardiology Monoterpene oxide Patch clamp Sodium channel Ventricular myocyte Rabbit |
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