| 促黑素受体在皮肤创伤愈合过程中的表达定位 |
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| 引用本文： | 高成,陈欢,李良海,金平,姚波. 促黑素受体在皮肤创伤愈合过程中的表达定位[J]. 创伤外科杂志, 2015, 0(1): 57-61 |
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| 作者姓名： | 高成 陈欢 李良海 金平 姚波 |
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| 作者单位： | 1. 华中科技大学同济医学院附属荆州医院, 湖北,423000;2. 重庆科技学院化学化工学院生物与制药系, 重庆,401331 |
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| 基金项目： | 第三军医大学创伤、烧伤与复合伤国家重点实验室开放基金资助项目( SKLKF201203)；重庆市教委科学技术研究项目 |
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| 摘 要： | 目的：观察皮肤创面愈合过程中促黑素受体（ MC1R）是否表达于创面皮肤以及动态变化过程。方法制作大鼠皮肤创面，分别使用HE染色和免疫组织化学方法观察皮肤创伤后1、3、5、7、14、21d皮肤创面愈合过程中MC1R的表达定位变化。结果在创面愈合过程中MC1R表达于创面周围炎性细胞、新生成基底层细胞，且阳性细胞向创面中心聚集。结论创面愈合过程中MC1R的时空表达特性提示MC1R参与创面愈合且与配体结合后可能对创面愈合炎症反应有调控作用。
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| 关 键 词： | 创面愈合 促黑素受体 促黑素 |
Expression of the melanocortin 1receptor during wound healing |
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| GAO Cheng,CHEN Huan,LI Liang-hai,JIN Ping,YAO Bo. Expression of the melanocortin 1receptor during wound healing[J]. Journal of Traumatic Surgery, 2015, 0(1): 57-61 |
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| Authors: | GAO Cheng CHEN Huan LI Liang-hai JIN Ping YAO Bo |
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| Affiliation: | GAO Cheng;CHEN Huan;LI Liang-hai;JIN Ping;YAO Bo;Jingzhou Hospital Affiliated to Tongji Medical College,Huzhong University of Science and Techndogy;Department of Biology and Pharmacevtica Engineering,College of Chemical Engineering,Chongqing University of Sciences and Technologyy; |
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| Abstract: | Objective To explore whether melanocortin 1 receptor ( MC1R) expresses in wounded skin and its dynamic change in the wound healing process .Methods Skin wounds in rats were made and HE staining and immunohistochemical method were employed to observe the change of MC 1R expression sites in the wound heal-ing process 1,3,5,7,14,21 days later respectively .Results The study found that MC1R expressed in inflammato-ry cells around the wound and newly-generated basal cells in the wound healing process .And as the wound healing gradually migrated to the wound center , the expression quantity gradually increased .Conclusion In the process of wound healing,the expression characteristics of MC1R suggest that MC1R/α-MSH participates in wound healing and may regulate inflammatory response in the process of wound healing . |
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| Keywords: | wound healing melanocortin 1 receptor melanocyte-stimulating hormone |
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