Mdm2、p53在乳腺癌中的表达及意义

目的研究Mdm2、P53蛋白在乳腺肿瘤组织中的表达及临床意义。方法应用免疫组化SP法检测Mdm2、P53蛋白在不同组织学类型乳腺癌60例、正常乳腺组织20例中的表达。结果Mdm2、P53蛋白在乳腺癌组织中阳性表达率与正常乳腺组织比较差异有统计学意义（P〈0．01）。Mdm2、P53蛋白表达与肿瘤大小比较无差异（P〉0．05），在临床分期、腋窝淋巴结转移之间比较差异有统计学意义（P〈0．01）。结论Mdm2、P53蛋白在乳腺癌组织中的异常表达，说明在乳腺癌的发生及发展中起重要作用。

Expression of P53 and MDM2protein in breast tumor

Objective To investigate the expression of anti-oncogene P53 and cancergeneMDM2 proteins and their significance inthe pathogenesis and progress of Breast tumor. Methods To detect the expression ofP53 andMDM2 in 60 cases of Breast tumor and 20 cases of normal Breast tissue with immunoh is to chemical method. Results The positive rate of P53 in the tissues of the 60 cases of breast tumor is much higher than it in the 20 cases of normal breast tissues. There is statistical significance in the disparity (P ＜ 0. 01). Mdm2, P53protein expression and tumor size was no difference (P ＞ 0. 05) , clinical stage, axillary lymph node metastasis was significant difference(P ＜ 0. 01). Conclusion Both P53 andMDM2 participate in the pathogenesis and progress of breast tumor and they can be considered as the biological index to evaluate breast tumor.