| HBV相关性原发性肝癌行综合治疗后HBV炎症与肿瘤复发的关系 |
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| 引用本文： | 吕凌,王学浩,成峰,夏永祥,邵文雨,王海,孙倍成,李国强. HBV相关性原发性肝癌行综合治疗后HBV炎症与肿瘤复发的关系[J]. 江苏医药, 2011, 37(11) |
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| 作者姓名： | 吕凌 王学浩 成峰 夏永祥 邵文雨 王海 孙倍成 李国强 |
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| 作者单位： | 南京医科大学第一附属医院肝移植中心,210029 |
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| 摘 要： | 目的总结乙型肝炎病毒(HBV)相关性原发性肝癌(肝癌)肝叶切除为主的综合治疗后HBV炎症与肿瘤复发之间的关系。方法回顾性分析646例肝癌患者的临床资料。采用Kaplan-Meier法计算肝癌行肝切除术为主的综合治疗后生存率和无瘤生存率,Log-rank检验比较组间差异。结果 646例肝癌患者行肝切除术为主的综合治疗后1、3和5年总生存率分别为76.12%、52.65%和38.18%,无瘤生存率分别为82.54%、62.17%和41.90%。HBV低复制组1年肿瘤复发率为22.17%;HBV高复制组1年肿瘤复发率为47.32%。两者比较差异有统计学意义(P<0.05)。结论 HBV的复制程度是影响肝癌综合治疗患者生存率及无复发生存率的独立预后因素,抗病毒治疗可以抑制病毒复制,延缓肿瘤复发,延长生存时间。
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| 关 键 词： | 乙型肝炎病毒 原发性肝癌 |
Clinical analysis on HBV activation and carcinoma recurrence after hepatectomy in patients with HBV infection-related hepatocellular carcinoma |
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| LV Ling,WANG Xuehao,CHENG Feng,et al.. Clinical analysis on HBV activation and carcinoma recurrence after hepatectomy in patients with HBV infection-related hepatocellular carcinoma[J]. Jiangsu Medical Journal, 2011, 37(11) |
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| Authors: | LV Ling WANG Xuehao CHENG Feng et al. |
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| Affiliation: | LV Ling,WANG Xuehao,CHENG Feng,et al.Liver Transplantation Center,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA |
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| Abstract: | Objective To summarize the outcomes of hepatectomy in patients with HBV infection-related hepatocellular carcinoma(HCC).Methods The data of 646 patients with HBV-related HCC underwent hepatectomy were retrospectively analyzed.The overall survival and recurrence rates were calculated with Kaplan-Meier survival curve.Results The 1-,3-and 5-year overall survival rates were 76.12%,52.65% and 38.18%,and the recurrence-free survival rates were 82.54%,62.17% and 41.90%.In the patients with low and high replication... |
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| Keywords: | HBV infection-related hepatocellular carcinoma |
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