| 生存素、FHIT、VEGF-C在胃腺癌中的表达及相关性 |
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| 引用本文： | 郭冉,李舒. 生存素、FHIT、VEGF-C在胃腺癌中的表达及相关性[J]. 江苏医药, 2011, 37(8) |
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| 作者姓名： | 郭冉 李舒 |
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| 作者单位： | 辽宁医学院附属第一医院消化病科,锦州市,121001 |
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| 基金项目： | 辽宁省教育厅2009年度高等学校科研项目计划(2009A474) |
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| 摘 要： | 目的探讨生存素(survivin)、脆性组氨酸三联体(FHIT)、血管内皮生长因子C(VEGF-C)在胃腺癌中的表达及其相关性。方法用半定量RT-PCR检测43例胃腺癌及对应癌旁、远癌正常组织中生存素、FHIT、VEGF-C mRNA的表达。结果胃腺癌组织中生存素、VEGF-C的mRNA表达水平明显高于癌旁和远癌正常组织,FHIT mRNA表达明显低于癌旁和远癌正常组织(P<0.05)。生存素、VEGF-C mRNA在胃腺癌中的表达均与肿瘤的分化、分期、浸润、淋巴结转移有关(P<0.05);FHIT mRNA在胃腺癌中的表达与肿瘤直径、分期、浸润、淋巴结转移有关(P<0.05)。胃腺癌中生存素与VEGF-C的mRNA表达呈正相关(P<0.05),生存素与FHIT的mRNA表达呈负相关(P<0.05)。结论生存素、VEGF-C表达增强与FHIT表达缺失共同促进胃癌的发生、发展。
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| 关 键 词： | 生存素 脆性组氨酸三联体 血管内皮生长因C 胃腺癌 |
Expressions and correlation of survivin,FHIT and VEGF-C in gastric adenocarcinoma |
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| GUO Ran,LI Shu. Expressions and correlation of survivin,FHIT and VEGF-C in gastric adenocarcinoma[J]. Jiangsu Medical Journal, 2011, 37(8) |
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| Authors: | GUO Ran LI Shu |
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| Affiliation: | GUO Ran,LI Shu.Department of Gastroenterology,First Affiliated Hospital,Liaoning Medical University,Jinzhou 121001,CHINA |
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| Abstract: | Objective To investigate the expressions and correlation of survivin,fragile histidine triad(FHIT) and vascular endothelial growth factor C(VEGF-C) in gastric adenocarcinoma.Methods The expressions of survivin,FHIT and VEGF-C mRNA were detected by semi-quantitative RT-PCR in cancer tissues,tumor-adjacent normal tissues and distal normal tissues of 43 gastric adenocarcinoma cases.Results Compared with tumor-adjacent normal tissues and distal normal tissues,the expressions of survivin and VEGF-C mRNA increase... |
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| Keywords: | Survivin Fragile histidine triad Vascular endothelial growth factor C Gastric adenocarcinoma |
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