| 那格列奈或联用二甲双胍对初诊2型糖尿病血糖波动性的作用 |
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| 引用本文： | 王晓华,王雪琴,陈金锋,吴刚,金艳. 那格列奈或联用二甲双胍对初诊2型糖尿病血糖波动性的作用[J]. 江苏医药, 2011, 37(12) |
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| 作者姓名： | 王晓华 王雪琴 陈金锋 吴刚 金艳 |
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| 作者单位： | 南通大学第二附属医院内分泌病科,226001 |
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| 摘 要： | 目的 观察那格列余或联用二甲双胍对初诊2型糖尿病血糖波动性的作用.方法 60例初诊2型糖尿病患者分为单纯那格列奈治疗组(A组,28例)、那格列奈联合二甲双胍治疗组(B组,32例).人院后检测患者体重指数(BMI)、糖化血红蛋白(HbAlc)等指标;同时采用动态血糖监测系统(CGMS)进行连续72 h血糖监测,以平均血糖标准差(SDBG)、日内平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)反映血糖波动性.治疗3个月后随访复查上述指标.结果 治疗前,B组BMI高于A组(P＜0.05),两组HbA1c、SDBG、MAGE、MODD差异无统计学意义(P＞0.05);治疗后,B组BMI较治疗前降低(P＜0.05),两组HbA1c、SDBG、MAGE、M0DD均分别较治疗前明显改善(P＜0.05).结论 初诊2型糖尿病患者单用那格列奈,或BMI较高患者那格列奈联用二甲双胍治疗,不仅能有效降低血糖,而且能改善血糖波动.
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| 关 键 词： | 那格列奈 2型糖尿病 |
Effect of nateglinide or combined with metformin treatment on glycemic excursion in newly diagnosed type 2 diabetes |
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| WANG Xiaohua,WANG Xueqin,CHEN Jinfeng,et al.. Effect of nateglinide or combined with metformin treatment on glycemic excursion in newly diagnosed type 2 diabetes[J]. Jiangsu Medical Journal, 2011, 37(12) |
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| Authors: | WANG Xiaohua WANG Xueqin CHEN Jinfeng et al. |
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| Affiliation: | WANG Xiaohua,WANG Xueqin,CHEN Jinfeng,et al.Department of Endocrinology,Second Affiliated Hospital,Nantong University,Nantong 226001,CHINA |
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| Abstract: | Objective To study the effect of treatment with nateglinide or combined with metformin on glycemic excursion in newly diagnosed type 2 diabetes mellitus(T2DM).Methods Sixty patients with newly diagnosed T2DM were treated with nateglinide(group A,28 cases) or nateglinide combined with metformin(group B,32 cases).Body mass index(BMI) and glycosylated hemoglobin 1c(HbA1c) were detected.The patients were observed by continuous glucose monitoring system for continuous 72 hours,glycemic excursion was reflected by... |
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| Keywords: | Nateglinide Type 2 diabetes mellitus |
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