桑菊饮加减方治疗感染后咳嗽风热阴伤证临床研究

目的:研究探讨桑菊止咳方治疗感染后咳嗽风热阴伤证的临床效果。方法:选择观察期间就诊的90例感染后咳嗽风热阴伤证患者,按照随机数字表法划分为两组,各45例,对照组给予常规西药治疗,观察组在常规西药治疗基础上加用桑菊饮加减方治疗,比较两组的临床疗效、中医证候积分、症状缓解时间、血清炎症因子指标、免疫球蛋白指标、不良反应发生率。结果:观察组的总有效率95.56%高于对照组的80.00%(P<0.05),其咳嗽、咽痒等症状缓解时间(3.98±1.05) d、(2.59±0.62)d均短于对照组的(4.27±1.36)d、(3.46±0.87)d(P<0.05)。治疗后观察组的咳嗽咳痰、胸闷气短、咽痒口干、声音嘶哑等积分(1.37±0.31)分、(1.55±0.36)分、(1.34±0.38)分、(1.36±0.29)分均低于对照组的(1.69±0.35)分、(1.91±0.38)分、(1.78±0.41)分、(1.72±0.37)分(P<0.05),其CRP(5.18±3.09)mg/L、IL-6(20.05±2.76)ng/L、TNF-α(8.43±2.92)mg/L均低于对照组的(8.50±3.27)mg/L、(23.24±3.07)ng/L、(11.86±3.71)mg/L(P<0.05)。观察组其IgG(11.75±1.34)g/L、IgA(3.09±0.41)g/L、IgM(1.46±0.29)g/L均高于对照组的(10.42±1.17)g/L、(2.68±0.37)g/L、(1.18±0.26)g/L(P<0.05)。观察组与对照组的不良反应总发生率分别为6.67%、4.44%,差异无统计学意义(P>0.05)。结论:在感染后咳嗽风热阴伤证患者西药治疗基础上应用桑菊饮加减方,可有效减轻患者临床症状,抑制其机体内炎症反应,提高其免疫力,且不会增加用药不良反应,兼具良好的临床疗效和安全性。

Clinical effect of Sangju Yin Jiajian in treating postinfection cough Fengre Shangyin syndrome

Objective:To study the clinical effect of Sangju Yin Jiajian in treating postinfection cough Fengre Shang Yin syndrome.Methods:90 patients with cough Fengre Shangyin after infection were randomly divided into two groups,45 cases in each group.The control group was treated with routine western medicine.The observation group was treated with Sangju Yin Jiajian on the basis of routine western medicine.The clinical efficacy,TCM syndrome score,symptom remission time,serum inflammatory factor index,immunoglobulin index and adverse reaction rate were compared between the two groups.Results:The total effective rate of the observation group (95.56%) was higher than that of the control group (80.00%)(P<0.05).The relief time of cough,pharynx itch and other symptoms in the observation group (3.98 ±1.05) d and (2.59 ±0.62) d were shorter than that in the control group (4.27 ±1.36) d,(3.46 ±0.87) d (P<0.05).After treatment,the scores of cough and expectoration,shortness of chest,dry pharynx and itching mouth,hoarseness of voice (1.37 ±0.31,1.55 ±0.36,1.34 ±0.38,1.36 ±0.29) in the observation group were lower than those in the control group (1.69 ±0.35,1.91 ±0.38,1.78 ±0.41,1.72±0.37),CRP (5.18 ±3.09) mg/L,IL-6 (20.05 ±2.76) ng/L;TNF-α(8.43 ±2.92) mg/L was lower than control group (8.50 ±3.27) mg/L,(23.24 ±3.07) ng/L,(11.86 ±3.71) mg/L (P<0.05),and its IgG was (11.75 ±1.34) g / L.IgA (3.09 ±0.41) g / L,IgM (1.46 ±0.29) g / L was significantly higher than that of control group (10.42 ±1.17) g / L,(2.68 ±0.37) g / L,(1.18 ±0.26) g / L (P<0.05).The total incidence of adverse reactions in the observation group and the control group was 6.67 and 4.44.The difference was not statistically significant (P >0.05).Conclusion:The application of Sangju Yin Jiajian on the basis of western medicine treatment in patients with cough Fengre Shangyin syndrome after infection can effectively alleviate the clinical symptoms of the patients,suppress the inflammatory reaction in the body,improve their immunity,and not increase the adverse drug reactions.Both good clinical efficacy and safety.