益气活血化痰通络方对颈动脉粥样硬化患者T细胞亚群影响的研究

目的:观察益气活血化痰通络方对颈动脉粥样硬化患者T细胞亚群的影响。方法:将61例诊断为颈动脉粥样硬化且中医辨证为气虚痰瘀证的老年患者(年龄≥60岁)随机分为治疗组(益气活血化痰通络方每日1剂加阿托伐他汀20 mg/d)与对照组(阿托伐他汀20 mg/d),治疗周期为12周。用药前后,观察两组T细胞亚群、血脂及中医证候的变化。结果:两组具有基线同质性,治疗12周后,治疗组中医证候改善优于对照组(P<0.01)。治疗组低密度脂蛋白低于对照组(P<0.05)。治疗组Th细胞、Th/Ts、NK细胞低于对照组(P<0.05)。治疗前后,两组患者血常规、肝功能、肾功能等安全指标未出现明显异常。结论:益气活血化痰通络方可以调节颈动脉粥样硬化患者的T细胞亚群水平,其作用机制可能与改善炎症反应有关。

Effect of Yiqi Huoxue Huatan Tongluo formula on T-cells subset in patients with carotid atherosclerosis

Objective:To observe the T-cells subset of patients with carotid atherosclerosis after treatment of Yiqi Huoxue Huatan Tongluo formula.Methods:61 patients with carotid atherosclerosis of which TCM syndrome were Qi deficiency and sputum stasis(age≥60) were randomly divided into control group(atorvastatin 20 mg/d) and treatment group(Yiqi Huoxue Huatan Tongluo Fang plus with atorvastatin 20 mg/d).The duration of therapy was 12 weeks.The T-cells subset,blood lipid levels and TCM syndrome score were observed before and after 12-week treatment.Results:The two groups had baseline homogeneity.After 12-week treatment,the TCM syndrome response to therapy was better than control group(P<0.01).The LDL of treatment group was lower than control group(P<0.05).The Th cells,Th/Ts and NK cells of treatment group were lower than control group(P<0.05).There were no statistical differences in blood routine examination,liver function and renal function.Conclusion:Yiqi Huoxue Huatan Tongluo formula can regulate T-cells subset level patients with carotid atherosclerosis,which mechanism was concerned with improving inflammatory response.