鼻咽癌患者血清同型半胱氨酸水平与临床病理特征的相关性分析

目的 研究鼻咽癌患者血清同型半胱氨酸(HCY)水平与临床病理特征的相关性,以及HCY在鼻咽癌疗效监测及预后判断中的作用。方法 选取郴州市第一人民医院南院2017年3月～2018年3月初次经病理确诊未经治疗的鼻咽癌患者作为观察组(n=72),体检中心就诊的健康体检人群作为对照组(n=81)。采集鼻咽癌患者治疗前、健康体检者当日空腹静脉血,离心分离血清,采用循环酶法检测血清HCY。比较两组人群的血清HCY水平,分析血清HCY水平与鼻咽癌患者临床病理特征的相关性。结果 鼻咽癌患者血清HCY为14.44±4.24 μmol/L,健康体检人群血清HCY为10.96±2.06 μmol/L。鼻咽癌患者、健康体检人群血清HCY异常率分别为93.05%(67/72)和58.02%(47/81)。鼻咽癌患者血清HCY水平、HCY异常率明显高于健康体检人群,差异有统计学意义(t=-6.331,P<0.05; t=24.629,P<0.05)。血清HCY诊断鼻咽癌的敏感度为93.05%(67/72),特异度为41.98%(34/81)。血清HCY水平与鼻咽癌患者年龄、性别、肿瘤的分化程度以及临床分期相关(t=2.011,-2.673,-2.303,-2.409,均P<0.05); 与鼻咽癌浸润深度、淋巴结转移及远处转移无关(t=0.042,0.537,0.238,均P>0.05)。结论 鼻咽癌患者血清HCY水平明显升高,且与年龄、性别、肿瘤分化程度以及临床分期相关。血清HCY有望成为鼻咽癌疗效监测及预后判断的肿瘤标志物。

Correlation Analysis between Serum Homocysteine Level ofNasopharyngeal Carcinoma Patients and Clinical Pathological Features

Objective To study the correlation between thelevels of serum homocysteine and the clinical pathological features of nasopharyngeal carcinoma patients,and the role of homocysteine in therapeuticeffect monitoring and prognosis judgement of nasopharyngeal carcinoma.Methods 72 patients with nasopharyngeal carcinoma who were diagnosed by pathology for the first time without treatment from March 2017 to March 2018 in the South Hospital of the First People's Hospital of Chenzhou City were selected as the observation group.The 81 healthy subjects in the physical examination center were treated as the control group.Fasting venous blood was collected from patients with nasopharyngeal carcinoma before treatment and those who underwent physical examination on the same day.Then the samples were centrifugedto separate serum for experiment.Serum homocysteine levels were measured by cycling enzymatic method.Serum homocysteine level of the two groups was compared by statistics.The correlation between the serum homocysteine levels and clinicalpathological features of nasopharyngeal carcinoma patients was been studied.Results The serum homocysteine level of nasopharyngeal carcinoma patients and the health examination population was 14.44±4.24 μmol/Land 10.96±2.06 μmol/L respectively.The serum homocysteine abnormal rate was93.05%(67/72)in nasopharyngeal carcinoma patients,and 58.02%(47/81)in thehealth check-up crowd.The serum homocysteine levels,homocysteine abnormal rate of nasopharyngeal carcinoma patients was significantly higher than that of healthy check-up crowd,and the distinction had statistical signification(P<0.05).The sensitivity of the serum homocysteine in the diagnosis of nasopharyngealcarcinoma was 93.05%(67/72),and the specificity was 41.98%(34/81).The serum homocysteine level was associated with the tumor differentiation and clinical stages of nasopharyngeal carcinoma(t=2.011,-2.673,-2.303,-2.409,all P<0.05),not associated with the infiltration depth,lymph node metastasis and distant metastasis(t=0.042,0.537,0.238,all P>0.05).Conclusion The serum homocysteine concentration of nasopharyngealcarcinoma patients was significantly elevated,and it was correlated with age,gender,degree of tumor differentiation and clinical stage.Serum homocysteine isexpected to become tumor markers for curative effect and prognosis judgement of nasopharyngeal carcinoma.