脑血疏口服液治疗血管性认知功能障碍临床研究

目的:观察脑血疏口服液对血管性认知功能障碍(VCI)患者的临床疗效及对认知功能影响。方法:选取VCI患者80例,随机分为两组各40例,治疗组给予脑血疏口服液,每次10ml,3次/d,对照组给予尼莫地平,每次30mg,3次/d,为期6个月,分别于治疗前后对认知能力、日常生活能力进行评价,并检测两组患者的血液粘度,统计不良反应发生率。结果:治疗后1月、3月、6月两组简易精神状态量表(MMSE)、日常生活活动能力量表(ADL)评分均较治疗前有显著提高,差别有统计学意义(P<0.05),治疗后1个月,治疗组和对照组比较,差别无统计学意义(P>0.05),治疗后3个月、6个月治疗组MMSE、ADL评分较对照组提高明显,两组比较差异有统计学意义(P<0.05),治疗6个月后两组患者的红细胞压积、纤维蛋白原、血浆比粘度均较治疗前降低,具有统计学差异(P<0.05),但两组间比较差异无统计学意义(P>0.05),两组治疗前后实验室指标未见明显异常,未见严重不良反应。结论:脑血疏口服液能够改善患者日常生活能力和认知能力,对血管性认知功能障碍的远期效果明显优于尼莫地平组。

Effect observation on vascular cognitive impairment treated by Naoxueshu oral liquid

Objecive:To observe the clinical therapeutic effects of the Naoxueshu oral liquid in the treatment of patients with vascular cognitive impairment(VCI) and the influence on cognitive function.Methods:80 cases with VCI were randomly divided into treatment group and control group,with 40 cases in each group. Patients in the treatment group were given Naoxueshu oral liquid,10 ml at a time,three times per day,while others in the control group were treated with nimodipine,30 mg a time,three times per day. Both groups received six-month treatment. Cognitive ability,activity of daily living before and after treatment were evaluated and dynamical parameters of cerebral circulation were detected. The incidence of adverse reactions was statistically analyzed.Results:After 1,3,6 months of treatment,scores of Mini-mental state examination ( MMSE),Activity of daily living( ADL) were significantly higher than that of before the treatment in the two groups. The difference was statistically significant( P <0.05). After treatment of 1 months,there was no significant difference between the two groups( P >0.05). After 3,6 months of treatment,with obvious increases in the scores of MMSE and ADL when compared to the control group,the difference was statistically significant( P <0.05).Hematocrit,fibrinogen and plasma specific viscosity were significantly lower in the two groups than before treatment,the difference was statistically significant( P <0.05),but there was no significant difference between the two groups( P >0.05).Neither evident abnormalities nor side effects were detected before and after treatment in the test. Conclusion:Naoxueshu oral liquid can efficiently improve the daily living activity and cognitive function,the long-term effect of Naoxueshu oral liquid on patients with VCI was significantly better than that of nimodipine group.