中药熏洗对膝关节骨性关节炎患者膝关节功能、血管内皮生长因子、软骨寡聚基质蛋白水平的影响

目的:分析中药熏洗对膝关节骨性关节炎(KOA)患者膝关节功能、血管内皮生长因子(VEGF)、软骨寡聚基质蛋白(COMP)水平的影响。方法:选取KOA患者84例,根据治疗方法不同分为对照组和观察组。对照组采用热水熏洗,观察组患者采用中药熏洗(方用制川乌、制草乌、川芎各6g,川牛膝、红花、透骨草、当归、伸筋草、威灵仙、桑寄生、苏木、羌活、独活、乳香、没药各10g)。分析两组患者治疗后的临床效果。结果:治疗4周后,观察组患者VAS评分(1.10±0.54)分低于对照组(2.36±0.78)分;Lysholm's膝关节评分(89.21±7.68)分高于对照组(78.51±7.11)分;组间差异有统计学意义(P<0.05)。治疗后,观察组患者血清NF-KB、COMP、VEGF及关节滑液HIF-1α、MMP-13水平低于对照组,关节滑液BCL-2水平高于对照组,差异有统计学意义(P<0.05)。结论:中药熏洗治疗KOA可降低VEGF、COMP的表达水平,减轻患者疼痛,改善膝关节功能。

Effects of fumigation and washing on knee joint function,vascular endothelial growth factor,cartilage oligomeric matrix protein in patients with KOA

Objective:Analyze the effects of fumigation and washing of Chinese medicine on knee function,vascular endothelial growth factor (VEGF) and cartilage oligomeric matrix protein (COMP) in patients with osteoarthritis.Methods:84 patients with KOA were divided into two groups,control group and observation group.Control group were treated by hot water fumigation,the observation group were treated by traditional Chinese medicine fumigation (Chuanwu,Zhicaowu,Chuanqiong 6 g,Chuanniuxi,Honghua,Tougucao,Danggui,Shenjincao,Weilingxian,Sangjisheng,Sumu Qianghuo,Duhuo,Ruxiang,Moyao 10 g).Analyze the clinical effect of two groups of patients after treatment.Results:4 weeks later,the VAS score (1.10±0.54) of the observation group was lower than that of the control group (2.36±0.78),and the Lysholm's knee score (89.21±7.68) was higher than that of the control group (78.51±7.11),with statistically significant differences ( P <0.05).Before treatment,the two groups of patients with NF- kappa B,COMP,joint synovial fluid,COMP,and joint synovial fluid.There was no significant difference in the level of 3 ( P >0.05).After 4 weeks,the serum NF- kappa B,COMP,VE in the observation group were significantly different.The levels of GF,HIF-1 α and MMP-13 in synovial fluid were lower than those in control group,and the level of BCL-2 in synovial fluid was higher than that in control group ( P <0.05).Conclusion:Chinese medicine fumigation and washing therapy can reduce the expression of VEGF concomp,relieve pain and improve knee function.