补阳还五汤联合丹红注射液对缺血性脑卒中气虚血瘀证神经功能及血清神经生长因子、脑源性神经细胞营养因子的影响

目的:研究补阳还五汤加减联合丹红注射液对气虚血瘀型缺血性脑卒中恢复期患者神经功能及血清神经生长因子(NGF)、脑源性神经细胞营养因子(BDNF)水平的影响。方法:选取气虚血瘀型缺血性脑卒中恢复期患者94例,根据治疗方案不同分为研究组(n=47)和对照组(n=47)。两组均给予常规药物治疗,于此基础上,对照组采用丹红注射液治疗,研究组于对照组基础上加用补阳还五汤加减治疗,2周为1个疗程,两组均持续治疗3个疗程。对比两组治疗前后神经功能缺损(NIHSS评分)、中医证候积分、血清NGF、BDNF水平、生活质量(SF-36评分)、血液流变学指标血小板聚集指数(PAG)、血浆纤维蛋白原(FIB)、红细胞聚集指数(EAI)]变化情况及中医临床效果。结果:治疗后两组NIHSS评分及中医证候积分均低于治疗前,且研究组低于对照组(P<0.05)。研究组治疗总有效率95.74%(45/47)高于对照组76.60%(36/47)(P<0.05)。治疗后两组血清NGF、BDNF水平均高于治疗前,且研究组高于对照组(P<0.05)。治疗后,两组PAG、FIB、EAI水平均低于治疗前,且研究组低于对照组(P<0.05)。治疗后,两组SF-36各项评分均高于治疗前,且研究组高于对照组(P<0.05)。结论:补阳还五汤加减联合丹红注射液治疗气虚血瘀型缺血性脑卒中恢复期患者,能显著提高治疗效果及患者神经功能,改善血液流变学指标及血清NGF、BDNF水平,并进一步提高患者生活质量。

Effect of Buyang Huanwu decoction combined with Danhong injection on neurological function,serum NGF and BDNF levels in patients with Qixu Xueyu type of ischemic stroke

Objective:To study the effect of neurological function and serum nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in patients with Qixu Xueyu type of ischemic stroke during the recovery period combined with Danhong injection.Methods:94 patients with Qixu Xueyu type ischemic stroke were enrolled.According to the treatment plan,they were divided into study group ( n =47) and control group ( n =47).The two groups were given conventional drug treatment.On the basis of this,the control group was treated with Danhong injection.The study group was treated with Buyang Huanwu decoction on the basis of the control group,and the treatment was continued for 2 weeks.Both groups have continued treatment for 3 courses.Compare neurological deficits (NIHSS score),TCM syndrome scores,serum NGF,BDNF levels,quality of life (SF-36 score),hemorheology index platelet aggregation index (PAG),plasma fibrinogen (FIB) before and after treatment,changes in erythrocyte aggregation index (EAI) and clinical effects of Chinese medicine.Results:After treatment,the NIHSS score and TCM syndrome scores of the two groups were lower than those before treatment,and the study group was lower than the control group (P<0.05).Study group The total effective rate of treatment was 95.74%(45/47) higher than that of the control group 76.60%(36/47)(P<0.05).After treatment,the serum levels of NGF and BDNF were higher than those before treatment.The study group was higher than the control group (P<0.05).After treatment,the levels of PAG,FIB and EAI in the two groups were lower than before treatment,and the study group was lower than the control group (P<0.05).After treatment,the scores of SF-36 in both groups were higher than that before treatment, and the study group was higher than the control group (P<0.05).Conclusion:Buyang Huanwu decoction combined with Danhong injection in the treatment of patients with Qixu Xueyu type ischemic stroke recovery can significantly improve the therapeutic effect,improve the neurological function of patients,improve blood rheology index and serum NGF,BDNF levels and further improve the quality of life of patients.