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EVALUATION OF GLYCOPYRROLATE AND ATROPINE AS ADJUNCTS TO REVERSAL OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS IN A "TRUE-TO-LIFE" SITUATION |
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| Authors: | COZANITIS, D. A. DUNDEE, J. W. MERRETT, J. D. JONES, C. J. MIRAKHUR, R. K. |
| Affiliation: | Department of Anaesthetics, The Queen's University of Belfast Belfast, Northern Ireland Department of Medical Statistics, The Queen's University of Belfast Redkiln Way, Horsham, W. Sussex A. H. Robins Co. Redkiln Way, Horsham, W. Sussex |
| Abstract: | Glycopyrrolate, a quaternary ammonium anticholinergic compound,and atropine were evaluated in combination with neostigminefor antagonism of non-depolarizing neuromuscular block. A totalof 641 patients were investigated in a "true-to-life" situation.The patients receiving glycopyrrolate with neostigmine had smallerchanges in heart rate than those who received atropine. Thiswas particularly apparent in patients with cardiovascular disease. * Present address: Department of Anaesthesia, University CentralHospital, 00290 Helsinki, 29, Finland. |
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