| 中性粒细胞在慢性阻塞性肺疾病中的作用 |
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| 引用本文： | 欧莉梅,钟小宁.中性粒细胞在慢性阻塞性肺疾病中的作用[J].国际呼吸杂志,2008,28(11):671-675. |
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| 作者姓名： | 欧莉梅 钟小宁 |
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| 作者单位： | 广西医科大学第一附属医院呼吸内科,南宁,530021 |
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| 摘 要： | 慢性阻塞性肺疾病(chronic obstructive pneumonia discase,COPD)是以不完全可逆的气流受限为特征的慢性炎症性疾病.中性粒细胞可能在COPD的发展过程中发挥主要作用.活化的中性粒细胞释放蛋白酶、活性氧和细胞因子,引起肺组织损伤,最终导致气道黏液高分泌,气流受限和肺气肿.
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| 关 键 词： | 中性粒细胞 慢性阻塞性肺疾病 炎症 |
Role of neutrophils in chronic obstructive pulmonary disease |
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| OU Li-mei,ZHONG Xiao-ning.Role of neutrophils in chronic obstructive pulmonary disease[J].International Journal of Respiration,2008,28(11):671-675. |
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| Authors: | OU Li-mei ZHONG Xiao-ning |
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| Abstract: | Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory condition characterized by irreversible airflow limitation.Neutrophils are likely to play a major role in the progression of COPD.Activated neutrophils release neutrophil elastases,reactive oxygen species and cytokines which result in lung tissue damage.Finally,this leads to mucus hypersecretion,airflow limitation and emphysema. |
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| Keywords: | Neutrophil Chronic obstructive pulmonary disease Inflammation |
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