| 基于RNA干扰技术和microRNA调控的丙型肝炎治疗研究进展 |
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| 引用本文： | Liu YN,Lou GH,Chen Z. 基于RNA干扰技术和microRNA调控的丙型肝炎治疗研究进展[J]. 浙江大学学报(医学版), 2011, 40(6): 609-616. DOI: 10.3785/j.issn.1008-9292.2011.06.007 |
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| 作者姓名： | Liu YN Lou GH Chen Z |
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| 作者单位： | 传染病诊治国家重点实验室;浙江大学医学院附属第一医院传染病研究所,浙江杭州310003 |
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| 基金项目： | 国家"十二五"科技重大专项,国家自然科学青年基金 |
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| 摘 要： | 丙型肝炎病毒(HCV)感染是一个全球性的健康问题,全球约有1.7亿人感染了HCV,慢性丙型肝炎常导致肝硬化、肝癌等严重的肝脏疾病,但至今尚无针对HCV感染的有效疫苗或抗体.RNA干扰(RNAi)是一种抵御病毒感染的最具前景的治疗策略,近年来基因治疗领域的发展进一步提升了其临床应用的可行性.RNAi技术加速了对HCV生物学基础的认知,并揭示了许多可作为治疗新靶点的病毒和宿主细胞分子.同时,基因运载体系的发展以及microRNA (miRNA)在HCV感染中关键作用的发现,使得基于RNAi和miRNA的抗病毒治疗策略具有巨大前景.文中就丙型肝炎治疗的RNAi靶点,肝脏靶向基因运载体系,microRNAs抗HCV感染潜能等研究领域中的最新进展作一综述.
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| 关 键 词： | 肝炎病毒属 RNA干扰 微RNAs 肝炎,丙型/治疗 丙型肝炎病毒 RNA干扰 短发卡RNA 小RNA |
Research advances on treatment of hepatitis C infection based on RNA interference and microRNA modulation |
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| Liu Yan-ning,Lou Guo-hua,Chen Zhi. Research advances on treatment of hepatitis C infection based on RNA interference and microRNA modulation[J]. Journal of Zhejiang University. Medical sciences, 2011, 40(6): 609-616. DOI: 10.3785/j.issn.1008-9292.2011.06.007 |
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| Authors: | Liu Yan-ning Lou Guo-hua Chen Zhi |
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| Affiliation: | LIU Yan-ning,LOU Guo-hua,CHEN Zhi(State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China) |
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| Abstract: | Infection with hepatitis C virus(HCV) is one of the major global health problems,approximately 170 million people are infected worldwide.The chronic HCV infection is associated with a high risk of developing liver cirrhosis,hepatocellular carcinoma(HCC) and liver failure.Unfortunately,there is still no effective vaccine or antibodies available for the prevention of infection.RNA interference(RNAi) represents a promising new approach to combat viral infections,and recent developments in the field of gene the... |
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| Keywords: | Hepacivirus RNA interference MicroRNAs Hepatitis C/ther HCV RNAi shRNA miRNA |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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