| NMDA受体依赖的神经元存活及保护作用的机制 |
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| 作者姓名： | Do S Luo JH Qiu S |
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| 作者单位： | 浙江大学医学院神经生物系、卫生部医学神经生物学重点实验室,浙江杭州,310058 |
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| 基金项目： | 国家“蛋白质重大科学研究计划”项目,国家自然科学基金重点项目,浙江省自然科学基金 |
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| 摘 要： | NMDA受体属于谷氨酸受体,它在突触传递和突触可塑性中都发挥着非常重要的作用,其介导的兴奋性毒性是脑缺血、缺氧和脑外伤等导致脑损伤的重要分子机制.但是,近年来的研究发现,在生理和某些病理情况下,NMDA受体的激活具有促进神经元存活及保护神经元免受损伤的作用.
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| 关 键 词： | 脑损伤 药物疗法 神经元 药物作用 突触传递 NMDA受体 存活 机制 |
Mechanism of NMDA receptor-dependent neuronal survival and neuroprotection |
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| Do S,Luo JH,Qiu S.Mechanism of NMDA receptor-dependent neuronal survival and neuroprotection[J].Journal of Zhejiang University(Medical Sciences),2011,40(4):440-445. |
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| Authors: | Do Song Luo Jian-hong Qiu Shuang |
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| Institution: | Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China. |
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| Abstract: | NMDA (N-methyl-D-aspartate) receptors are a subtype of glutamate receptor, and play an important role in both synaptic transmission and synaptic plasticity. When excessively excited, NMDA receptors can cause cell death in many neuropathological scenarios such as OGD (oxygen and glucose deprivation) and brain injury. However, recent studies have revealed that under the physical and some pathological conditions, NMDA receptor could promote neuronal survival and protect neurons from damage. |
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