| 合用氟喹诺酮类药物对金黄色葡萄球菌突变选择窗的影响 |
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| 引用本文： | 江玲 ,王慧玲,庚俐莉,刘春芳.合用氟喹诺酮类药物对金黄色葡萄球菌突变选择窗的影响[J].大连医科大学学报,2011,33(3):255-258. |
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| 作者姓名： | 江玲 王慧玲 庚俐莉 刘春芳 |
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| 作者单位： | 江玲,庚俐莉,刘春芳,JIANG Ling,GENG Li-li,LIU Chun-fang(大连市中心医院呼吸内科,辽宁大连,116033);王慧玲,WANG Hui-ling(大连医科大学附属第二医院呼吸内科,辽宁大连,116027) |
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| 摘 要： | 目的]探讨FQ药物联合用药对金黄色葡萄球菌突变选择窗(MSW)的影响.方法]采用琼脂二倍稀释法测定3种药物对38株临床分离金黄色葡萄球菌株和金黄色葡萄球菌质控菌株ATCC25923的最低抑菌浓度(MIC)以及两种FQ的防突变浓度(MPC),计算FQ单药和联合用药后的MPC50、MPC90、MPC/MIC选择指数(...
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| 关 键 词： | 氟喹诺酮 联合用药 金黄色葡萄球菌 防突变浓度 |
Study of the effect of fluroquinolone combination on the mutant selection window (MSW) of Staphylococcus aureus |
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| JIANG Ling,WANG Hui-ling,GENG Li-li and LIU Chun-fang.Study of the effect of fluroquinolone combination on the mutant selection window (MSW) of Staphylococcus aureus[J].Journal of Dalian Medical University,2011,33(3):255-258. |
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| Authors: | JIANG Ling WANG Hui-ling GENG Li-li and LIU Chun-fang |
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| Institution: | JIANG Ling1,WANG Hui-ling2,GENG Li-li1,LIU Chun-fang1(1.Department of Respiratory Medicine,Dalian Center Hospital,Dalian 116033,China,2.Department of Respiratory Medicine,the Second Affiliated Hospital of Dalian Medical University,Dalian 116023) |
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| Abstract: | Objective] To study the effect of fluroquinolone combination on the mutant selection window(MSW) of staphylococcus aureus in vitro.Methods] MIC for 38 clinical isolates of staphylococcus aureus and quality control(ATCC25923) were determined by the standard two fold agar dilution methods.MPC of fluoroquinolones against strains were determined by agar dilution methods.The values of MPC50,MPC90 and MPC/MIC were calculated.SPSS statistics software was used to analyze the data.Results] After combined with cep... |
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| Keywords: | fluoroquinolon drug combination staphylococcus aureus mutant prevention concentration |
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