大蒜汁雾化吸入联合GP方案治疗中晚期非小细胞肺癌57例疗效观察

【目的】观察大蒜汁雾化吸入联合GP方案[吉西他滨（GEM）＋顺铂（DDP）]治疗中晚期非小细胞肺癌（NSCLC）的临床疗效、不良反应及对白细胞介素一6（IL一6）的影响。【方法】将113例中晚期NSCLC患者随机分为两组，治疗组（57例）采用大蒜汁雾化吸入加GP方案治疗，对照组（56例）采用单纯GP方案化疗。【结果】治疗组和对照组的有效率（CR＋PR）分别为45．6％和33．9％（P〉O．05），临床获益率（CR＋PR＋SD）分别为80．7％和64．3％（P〈0．05）。治疗后治疗组IL一6明显降低（P〈0．05）；治疗组生存质量高于对照组（P〈0．05）；对照组白细胞减少、血红蛋白下降和恶心、呕吐等病例数多于治疗组（P〈0．05）。【结论】大蒜汁雾化吸入与化疗同时应用治疗NSCLC，能降低炎症因子IL一6及减轻化疗的某些不良反应，提高临床获益率，改善患者生存质量。

Observation on the Efficacy of Atomized Inhalation of Water Extract from Garlic with GP Regimen in Treating 57 Cases with Advanced Non-small Cell Lung Cancer

[ObjectiveITo observe the clinical efficacy and adverse reaction of atomized inhalation of water extract form garlic combined with GP regimen gemcitabine（GEM） and cisplatin（DDP） for treating middle and advanced non-small lung cancer（NSCLC） and its effect on interleukin-6 （IL-6）. [Methods]Totally 113 cases of middle and advanced NSCLC were randomly divided into two groups. The treatment group（ n =57） was given atomized inhalation of water extract from garlic combined with GP regimen. The control group（ n =56） was given only GP regimen. [ResultsIThe effective rate（CR＋ PR） in treatment group and control group was 45.6% and 33.9%, respectively（ P〉0. 05）. The clinical benefit response rate（CR＋PR＋SD） in treatment group and control group was 80.7% and 64.3%, respectively（ P〈0.05）. After therapy, the level of IL-6 in treatment group significantly decreased（ P〈0.05）. The quality of life in treatment group was better than that in control group（ P〈0.05）. The incidence of leucopenia, hypohemoglobinemia, nausea and vomiting in con- trol group were higher than those in treatment group（ P d0.05）. [ConclusionIAtomized inhalation of water extract from garlic combined with chemotherapy for the treatment of NSCLC can decrease the level of IL-6 and some side effects, increase the clinical benefit response rate and improve the quality of life of the patients.