| 传统中药川乌炮制前后的离子阱质谱研究 |
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| 引用本文： | 董昕,刘敏,赵靖霞,张薇,娄子洋. 传统中药川乌炮制前后的离子阱质谱研究[J]. 药学实践杂志, 2009, 27(5): 349-352 |
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| 作者姓名： | 董昕 刘敏 赵靖霞 张薇 娄子洋 |
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| 作者单位： | 1. 第二军医大学药学院分析测试中心,上海,200433
2. 南京军区联勤部药品仪器检验所,江苏,南京,210002 |
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| 摘 要： | 目的：通过应用电喷雾－离子阱质谱，研究了炮制前后的川乌药材成分，以揭示川乌炮制减毒的原理。方法：对3种乌头对照品进行了离子阱多级质谱分析，归纳其裂解规律。对炮制前后的川乌药材进行液－质联用分析，并对各色谱峰进行归属。结果：通过对比炮制前后的质谱总离子流图及紫外色谱图，提出了川乌炮制减毒的两方面原因。结论：同时指出了将液－质联用技术引入中药炮制品的质量控制是十分必要的。
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| 关 键 词： | 川乌 离子阱质谱 炮制品 |
| 收稿时间： | 2009-07-07 |
Research on constituents of Radix Aconiti and its processing by electrospray ionization trap mass spectrometry |
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| DONG Xin,LIU Min,ZHAO Jing-xi,ZHANG Wei and LOU Zi-yang. Research on constituents of Radix Aconiti and its processing by electrospray ionization trap mass spectrometry[J]. The Journal of Pharmaceutical Practice, 2009, 27(5): 349-352 |
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| Authors: | DONG Xin LIU Min ZHAO Jing-xi ZHANG Wei LOU Zi-yang |
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| Affiliation: | Pharmaceutical Analysis Center, School of Pharmacy, the Second Military Medical University, SHANGHAI 200433, China;Institute for Drug and Instrument Control of Nanjing Command, Nanjing 210002, China;Pharmaceutical Analysis Center, School of Pharmacy, the Second Military Medical University, SHANGHAI 200433, China;Pharmaceutical Analysis Center, School of Pharmacy, the Second Military Medical University, SHANGHAI 200433, China;Pharmaceutical Analysis Center, School of Pharmacy, the Second Military Medical University, SHANGHAI 200433, China |
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| Abstract: | Objective: To reveal the processing principleg of preparation of Radix Aconiti by electrospray ionization trap mass spectrometry.Methods: The three reference standars were made MSn analysis and elucidating the fragmentation pathways.The rapid analysis by HPLC-ESI-MS had been used for identification of contituents in Radix Aconiti.Results:The comparison of mass spectra and liquid chromatographic information revealed the differences of Radix Aconiti and its process product.Conclusion: It is necessary to make quality control of process product of traditional Chinese herbal medicines by HPLC-ESI-MS. |
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| Keywords: | Radix Aconiti electrospray ionization trap mass spectrometry process product |
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