Smoothness of gait detects early alterations of walking in persons with multiple sclerosis without disability |
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| Affiliation: | 1. Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy;2. Multiple Sclerosis Centre, Department of Medical Sciences and Public Health University of Cagliari, Cagliari, Italy;1. Physical Therapy Program, Department of Physical Medicine and Rehabilitation, School of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop C244, 13121 E 17th Ave., Room 3108, Aurora, CO, 80045, United States;2. Department of Neurology, School of Medicine, University of Colorado Anschutz Medical Campus, Mail Stop B182, Research Complex 2, 12700 East 19th Ave., Aurora, CO, 80045, United States;3. Geriatric, Research, Education, and Clinical Center, VA Eastern Colorado Healthcare System, 1700 N Wheeling St., Aurora, CO, 80045, United States;1. Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy;2. Multiple Sclerosis Centre, Department of Medical Sciences and Public Health University of Cagliari, Cagliari, Italy;1. Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;2. Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Israel;1. Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Israel;2. Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel;1. Landon Center on Aging, University of Kansas Medical Center, 3901 Rainbow Blvd., Mail Stop 1005, Kansas City, KS 66160, United States;3. Department of Neurology, 3901 Rainbow Blvd., Kansas City, KS 66160, United States;4. Department of Physical Therapy and Rehabilitation Science, 3901 Rainbow Blvd., Mail Stop 2002, Kansas City, KS 66160, United States |
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| Abstract: | In people with Multiple Sclerosis (pwMS) with little or no signs of disability, early detection of walking impairments represents a challenging issue, as simple gait metrics (e.g. speed, cadence, stride length, etc.) may not significantly differ from those of healthy individuals. In this study, we aimed to assess the existence of possible differences in spatial-temporal parameters and smoothness of gait measures (assessed through Harmonic Ratio, HR) obtained from trunk accelerations between 50 pwMS without disability (Expanded Disability Status Scale score =1) and 50 age-matched healthy controls. The results show no differences in terms of gait velocity, stride length, stance/swing and double support phases duration, while HR in the direction of motion was significantly lower in pwMS (2.92 vs. 3.67, p < 0.001), thus indicating a less smooth gait. The study of trunk accelerations through calculation of HR represents a fast, non-intrusive technique that allows early identification of anomalies in gait patterns of pwMS in absence of disability. |
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| Keywords: | Gait Accelerometer Spatial-temporal parameters Low disability Harmonic ratio |
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