Healthy dietary patterns and incidence of biliary tract and gallbladder cancer in a prospective study of women and men |
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| Institution: | 1. University of Arizona College of Medicine—Tucson, 1501 N. Campbell Avenue, Tucson, AZ 85724, United States;2. University of Arizona Cancer Center, 1501 N. Campbell Avenue, PO Box 245017, Tucson, AZ 85724, United States;3. Department of Epidemiology and Biostatistics, University of Arizona Mel & Enid Zuckerman College of Public Health, 1295 N. Martin, PO Box 245211, Tucson, AZ 85724, United States;4. Department of Health Promotion Sciences, University of Arizona Mel & Enid Zuckerman College of Public Health, 3950 S. Country Club, Suite 330, Tucson, AZ 85714, United States;1. Division of Preventive Oncology, National Institute of Cancer Prevention and Research, Noida, India;2. Division of Molecular Oncology, National Institute of Cancer Prevention and Research, Noida, India;3. Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India;4. Department of Surgical Gastroenterology & Hepatology, GB Pant Hospital, New Delhi, India;5. Laboratory Oncology Unit, Rotary Cancer Center, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India;6. Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA;7. ICMR, New Delhi, India;8. India Cancer Research Consortium, Indian Council of Medical Research, New Delhi, India |
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| Abstract: | BackgroundWhether diet influences the risk of biliary tract cancer (BTC) is unknown. We examined the associations of two healthy dietary patterns, including a modified Dietary Approach to Stop Hypertension (mDASH) diet and a modified Mediterranean (mMED) diet, with the incidence of BTC in a population-based prospective study.MethodsThe study population comprised 76,014 Swedish adults who were 45–83 years of age and cancer-free at baseline. The mDASH and mMED diets were calculated from self-reported dietary data collected by a validated food-frequency questionnaire. Cox proportional hazards regression models were used to estimate hazard ratios (HR) with 95% confidence intervals (CI) adjusted for potential confounders.ResultsOver 1,010,777 person-years (mean 13.3 years) of follow-up, 140 extrahepatic BTC cases (including 77 gallbladder cancers) and 23 intrahepatic BTC cases were ascertained by linkage with the Swedish Cancer Register. Adherence to the mDASH and mMED diets was statistically significantly inversely associated with risk of extrahepatic BTC (Ptrend ≤ 0.0003) and gallbladder cancer (Ptrend ≤ 0.005) but not intrahepatic BTC (Ptrend ≥ 0.11). The multivariable HRs (95% CI) for the highest versus lowest tertile of the mDASH diet were 0.41 (0.26–0.64) for extrahepatic BTC and 0.36 (0.20–0.64) for gallbladder cancer. The corresponding HRs (95% CI) for the mMED diet were respectively 0.41 (0.25–0.67) and 0.42 (0.23–0.79).ConclusionAdherence to a healthy diet may play a role in reducing the risk of extrahepatic BTC. |
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| Keywords: | Biliary tract cancer Diet Foods Gallbladder cancer Prospective studies |
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