Omitting radiation therapy in women with triple-negative breast cancer leads to worse breast cancer-specific survival |
| |
| Institution: | 1. KU Leuven – University of Leuven, Department of Oncology, B-3000, Leuven, Belgium;2. University Hospitals Leuven, Department of Radiation Oncology, Herestraat 49, B-3000, Leuven, Belgium;3. Leuven Biostatistics and Statistical Bioinformatics Centre (L-Biostat), KU Leuven University, Kapucijnenvoer 35, B-3000, Leuven, Belgium;4. University Hospitals Leuven, Department of General Medical Oncology, Herestraat 49, B-3000, Leuven, Belgium;1. Department of Radiology, Stanford University, Stanford, California;2. Department of Radiology, Duke University Medical Center, Durham, North Carolina;3. Department of Radiology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina;4. Portsmouth Naval Medical Center, Portsmouth, Virginia;5. Department of Radiology, Medical University of South Carolina, Charleston, South Carolina;6. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas;1. Gastroenterology and Endoscopy Unit, ARNAS Civico-Di Cristina-Benfratelli Hospital, Palermo, Italy;2. Endoscopy Service, Department of Medicine, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), Palermo, Italy;3. Gastroenterology Unit, Villa Sofia – V. Cervello Hospital, Palermo, Italy;4. UOD Digestive Endoscopy, University of Messina, Messina, Italy;5. Endoscopic Surgery, ASP 5, Messina, Italy;6. Gastroenterology and Digestive Endoscopy Unit, San Raffaele-Giglio Hospital, Cefalù (PA), Italy;7. Gastroenterology Unit, ARNAS Garibaldi Hospital, Catania, Italy;8. Gastroenterology Unit, S. Vincenzo Hospital, Taormina (ME), Italy;1. Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, People''s Republic of China;2. Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, People''s Republic of China;3. Department of Oncology, Shanghai Medical College, Fudan University, PR China;4. Institutes of Biomedical Sciences, Fudan University, Shanghai, PR China;1. Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada;2. Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta, Canada;3. Department of Oncology, University of Calgary, Calgary, Alberta, Canada;4. Department of Radiation Oncology, Tom Baker Cancer Centre, Calgary, Alberta, Canada;5. Department of Radiation Medicine and Applied Sciences, University of California–San Diego, La Jolla, CA;6. Department of Radiation Therapy, Tom Baker Cancer Centre, Calgary, Alberta, Canada;1. Vanderbilt University School of Medicine, Nashville, Tennessee;2. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California;3. Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee;4. Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;6. Department of Chemical and Biomolecular Engineering, Vanderbilt University School of Engineering, Nashville, Tennessee |
| |
| Abstract: | PurposeTo examine locoregional recurrence (LRR) and breast cancer-specific survival (BCSS) after breast-conserving therapy (BCT) or mastectomy (ME) with or without radiation therapy (RT) in triple-negative breast cancer (TNBC).Material & MethodsWe identified non-metastatic TNBC cases from a single institution database. BCT, ME with RT (ME + RT) and ME only were compared with respect to LRR and BCSS. Cox regression models were used to analyze the association between prognostic factors and outcome.Results439 patients fulfilled the inclusion criteria. Median follow-up was 10.2 years (interquartile range 7.9; 12.4 years). Patients in the BCT (n = 239), ME + RT (n = 116) and ME only (n = 84) group differed with respect to age, pT, pN, lymphovascular invasion, lymph node dissection and chemotherapy administration. Ten-year LRR rates were seven percent, three percent and eight percent for the BCT, ME + RT and ME only group, respectively. pN was associated with LRR. In multivariable analysis LRR were significantly lower in the ME + RT group compared to the BCT and the ME only group (p 0.037 and 0.020, respectively).Ten year BCSS was 87%, 84% and 75% for the BCT, ME + RT and ME only group, respectively. pT, pN, lymph node dissection, lymphovascular invasion and the administration of chemotherapy were associated with BCSS. In multivariable analysis BCSS was significantly lower in the ME only group compared to the BCT group and the ME + RT group (p 0.047 and 0.003, respectively).ConclusionTNBC patients treated with ME without adjuvant RT showed significant lower BCSS compared to patients treated with BCT or ME + RT and significant more LRR compared to ME + RT when corrected for known clinicopathological prognostic factors. |
| |
| Keywords: | Triple-negative breast cancer Radiation therapy Breast-conserving therapy Mastectomy Indication |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
