Dendritic cells in host response to biologic scaffolds |
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| Affiliation: | 1. Materials Science Centre, Indian Institute of Technology Kharagpur, West Bengal 721302, India;2. Department of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India;1. BK21+ Nano-Integrated Cogno-Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 609-735, South Korea;2. Department of Optics and Mechatronics Engineering, College of Nanoscience & Nanotechnology, Pusan National University, Busan 609-735, South Korea;3. Division of Experimental Immunology, University of Tokushima, Tokushima 770-8503, Japan;4. Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine, Seoul 120-752, South Korea;1. Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK;2. National Heart and Lung Institute, Imperial College London, London, UK;3. Department of Materials Science and Metallurgy, University of Cambridge, Cambridge, UK;4. Division of Medicine and Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK;1. Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, United States;2. Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, United States;3. Center for Inflammation, Immunity and Infection, Georgia State University, Atlanta, GA 30303, United States |
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| Abstract: | Tissue regeneration and repair require a highly complex and orchestrated series of events that require inflammation, but can be compromised when inflammation is excessive or becomes chronic. Macrophages are one of the first cells to contact and respond to implanted materials, and mediate the inflammatory response. The series of events following macrophage association with biomaterials has been well-studied. Dendritic cells (DCs) also directly interact with biomaterials, are critical for specific immune responses, and can be activated in response to interactions with biomaterials. Yet, much less is known about the responses by DCs. This review discusses what we know about DC response to biomaterials, the underlying mechanisms involved, and how DCs can be influenced by the macrophage response to biomaterials. Lastly, I will discuss how biomaterials can be manipulated to enhance or suppress DC function to promote a specific desirable immune response – a major goal for implantable biologically active therapeutics. |
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| Keywords: | Immunomodulation innate immunity biomaterials extracellular matrix dendritic cell macrophage AIM" },{" #name" :" keyword" ," $" :{" id" :" kw0040" }," $$" :[{" #name" :" text" ," _" :" absent in melanoma ALR" },{" #name" :" keyword" ," $" :{" id" :" kw0050" }," $$" :[{" #name" :" text" ," _" :" AIM-like receptors CD" },{" #name" :" keyword" ," $" :{" id" :" kw0060" }," $$" :[{" #name" :" text" ," _" :" cluster of differentiation CLR" },{" #name" :" keyword" ," $" :{" id" :" kw0070" }," $$" :[{" #name" :" text" ," _" :" C-type lectin receptor DC" },{" #name" :" keyword" ," $" :{" id" :" kw0080" }," $$" :[{" #name" :" text" ," _" :" dendritic cell ECM" },{" #name" :" keyword" ," $" :{" id" :" kw0090" }," $$" :[{" #name" :" text" ," _" :" extracellular matrix FBR" },{" #name" :" keyword" ," $" :{" id" :" kw0100" }," $$" :[{" #name" :" text" ," _" :" foreign body reaction HMGB1" },{" #name" :" keyword" ," $" :{" id" :" kw0110" }," $$" :[{" #name" :" text" ," _" :" high mobility group box 1 protein IL" },{" #name" :" keyword" ," $" :{" id" :" kw0120" }," $$" :[{" #name" :" text" ," _" :" interleukin NLR" },{" #name" :" keyword" ," $" :{" id" :" kw0130" }," $$" :[{" #name" :" text" ," _" :" NOD-like receptors NOD" },{" #name" :" keyword" ," $" :{" id" :" kw0140" }," $$" :[{" #name" :" text" ," _" :" nucleotide-binding oligomerization domain MHC" },{" #name" :" keyword" ," $" :{" id" :" kw0150" }," $$" :[{" #name" :" text" ," _" :" major histocompatibility complex MMP" },{" #name" :" keyword" ," $" :{" id" :" kw0160" }," $$" :[{" #name" :" text" ," _" :" matrix metalloproteinase MyD88" },{" #name" :" keyword" ," $" :{" id" :" kw0170" }," $$" :[{" #name" :" text" ," _" :" myeloid differentiation primary response 88 PLGA" },{" #name" :" keyword" ," $" :{" id" :" kw0180" }," $$" :[{" #name" :" text" ," _" :" poly(lactic-co-glycolic acid) PRR" },{" #name" :" keyword" ," $" :{" id" :" kw0190" }," $$" :[{" #name" :" text" ," _" :" pattern recognition receptor RIG-I" },{" #name" :" keyword" ," $" :{" id" :" kw0200" }," $$" :[{" #name" :" text" ," _" :" retinoic acid-inducible gene 1 RLR" },{" #name" :" keyword" ," $" :{" id" :" kw0210" }," $$" :[{" #name" :" text" ," _" :" RIG-I-like receptor TIMP" },{" #name" :" keyword" ," $" :{" id" :" kw0220" }," $$" :[{" #name" :" text" ," _" :" tissue inhibitors of metalloproteinases TIR" },{" #name" :" keyword" ," $" :{" id" :" kw0230" }," $$" :[{" #name" :" text" ," _" :" Toll-IL-1 resistance TLR" },{" #name" :" keyword" ," $" :{" id" :" kw0240" }," $$" :[{" #name" :" text" ," _" :" Toll-like receptor TRIF" },{" #name" :" keyword" ," $" :{" id" :" kw0250" }," $$" :[{" #name" :" text" ," _" :" TIR-domain-containing adapter-inducing interferon-β |
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