Therapeutic efficacy of metronidazole by needle-free jet injection combined with blue light therapy in Moderate-to-Severe facial acne vulgaris |
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| Authors: | Lu Yi MM Lihua Gao PhD Lv Lv MD Bo Zhang MM Fangru Chen MD Fengyuan Yang MB Wenjie Yan MM Lijun Jiang MB Nianzhen Li MB Yuanqing Lao MB Jianyun Lu MD Xi Huang MD |
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| Affiliation: | 1. Department of Dermatology and Venereology/Cosmetic Dermatology, Affiliated Hospital of Guilin Medical University, Guilin, China;2. Departments of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China;3. Department of Breast and Thyroid surgery, Affiliated Hospital of Guilin Medical University, Guilin, China;4. Departments of Stomatology, The Third Xiangya Hospital, Central South University, Changsha, China |
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| Abstract: | Background Acne vulgaris is one of the most common dermatological diseases. Some topical treatments for acne used in combination, such as blue light and topical antibiotics (such as metronidazole) by needle-free jet injection (NFJI), are becoming prevalent in clinical practice, but the efficacy remains uncertain. Methods In order to investigate the effect of blue light combined with metronidazole by NFJI in the treatment of acne, the 251 enrolled patients were randomly assigned into the blue light group, metronidazole (MNZ) group, and MNZ + blue light group, and then received 6-weeks' treatment. A variety of objective and subjective methods such as clinical pictures, skin barrier physiological parameters (including trans-epidermal water loss (TEWL), stratum corneum hydration, facail surface sebum, erythema and pigmentation), the Investigator Global Assessment score, acne lesion count assessment, Patients' Self-Assessment, and VAS score were used to evaluate the efficacy and side effects of the treatments. Results Compared to the baseline, the MNZ + blue light group showed significant improvement in acne lesion count reduction, TEWL, straum corneum hydration, facial surface sebum and erythema (p < 0.05). The MNZ + blue light group showed significant differences compared with the MNZ group and blue light group in terms of acne lesion count reduction and erythema (p < 0.05) Compared to the MNZ group, the MNZ + blue light group demonstrated significant improvement in TEWL and sebum (p < 0.05). While compared to the blue light group, the MNZ + blue light group showed significant improvement in hydration (p < 0.05). There was no statistically significant difference among the three groups in pigmentation (p > 0.05). Conclusion The combination of MNZ by NFJI and blue light has a synergistic effect and can relieve acne skin lesion within 6 weeks in the treatment of moderate and moderate–to–severe facial acne vulgaris, meanwhile, this method has a good safety. |
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| Keywords: | acne blue light metronidazole needle-free jet injection skin barrier |
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