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A novel non-invasive model for the prediction of advanced liver fibrosis in chronic hepatitis B patients with NAFLD |
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| Authors: | Jian Wang Rui Huang Jiacheng Liu Ruimin Lai Yilin Liu Chuanwu Zhu Yuanwang Qiu Zebao He Shengxia Yin Yuxin Chen Xiaomin Yan Weimao Ding Qi Zheng Jie Li Chao Wu |
| Institution: | 1. Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China
Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, China;2. Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China;3. Department of Hepatology, Hepatology Research institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China;4. Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China;5. Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, China;6. Department of Infectious Diseases, The Fifth People's Hospital of Wuxi, Wuxi, China;7. Department of Infectious Diseases, Taizhou Enze Medical Center (Group) Enze Hospital, Taizhou, China;8. Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China Institute of Viruses and Infectious Diseases, Nanjing University, Nanjing, China;9. Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China;10. Department of Hepatology, Huai'an No. 4 People's Hospital, Huai'an, China |
| Abstract: | There are still lack of non-invasive models to evaluate liver fibrosis in chronic hepatitis B (CHB) patients with nonalcoholic fatty liver disease (NAFLD). We aimed to establish a predictive model for advanced fibrosis in these patients. A total of 504 treatment-naive CHB patients with NAFLD who underwent liver biopsy were enrolled and randomly divided into a training set (n = 336) and a validation set (n = 168). Receiver operating characteristic (ROC) curve was used to compare predicting accuracy for the different models. One hundred fifty-six patients (31.0%) had advanced fibrosis. In the training set, platelet, prothrombin time, type 2 diabetes, HBeAg positivity and globulin were significantly associated with advanced fibrosis by multivariable analysis. A predictive model namely PPDHG for advanced fibrosis was developed based on these parameters. The areas under the ROC curve (AUROC) of PPDHG with an optimal cut-off value of ?0.980 in predicting advanced fibrosis was 0.817 (95% confidence interval 0.772 to 0.862), with a sensitivity of 81.82% and a specificity of 66.81%. The predicting accuracy of PPDHG for advanced fibrosis was significantly superior to AST to platelet ratio index (APRI), fibrosis-4 score (FIB-4) and NAFLD fibrosis score (NFS). Further analysis revealed that the AUROC of PPDHG remained significantly higher than FIB-4 and NFS indexes, while it was comparable with APRI for predicting advanced fibrosis in the validation set. PPDHG had a better predicting performance than established models for advanced fibrosis in CHB patients with NAFLD. The application of PPDHG can reduce the necessary for liver biopsy in these patients. |
| Keywords: | chronic hepatitis B liver biopsy liver fibrosis nonalcoholic fatty liver disease predicting |