Carotid flow pulsatility is higher in women with greater decrement in gait speed during multi-tasking |
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| Affiliation: | 1. Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX, USA;2. Department of Rehabilitation Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, USA;3. Department of Human Development and Family Studies, Texas Tech University, Lubbock, TX, USA;1. Department of Geriatrics, Campus Bio-Medico University, Rome, Italy;2. Department of Geriatrics, Neurosciences, and Orthopaedics, Catholic University of Medicine, Rome, Italy;3. Institute of Neurology, Catholic University of Medicine, Rome, Italy;1. Program of Interdisciplinary Health Sciences, The University of Texas at El Paso, El Paso, TX, 79968, USA;2. Department of Kinesiology and Health, Georgia State University, P.O. Box 3975, Atlanta, GA, 30302, USA;1. Marquette University, P.O. Box 1881, Milwaukee, WI 53201, USA;2. Shriners Hospitals for Children – Chicago, 2211 N Oak Park Ave., Chicago, IL 60707, USA;3. Midwestern University, Physical Therapy Program, 555 31st St., Downers Grove, IL 60515, USA;1. Laboratory of Biomechanics and Medical Imaging, Faculty of Medicine, University of Saint-Joseph, Beirut, Lebanon;2. Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers ParisTech, Paris, France;3. Spine division, Hospital for Special Surgery, New York, USA;4. Hôtel-Dieu de France Hospital, University of Saint-Joseph, Beirut, Lebanon;1. APDM, Inc., 2828 SW Corbett Avenue, Portland, OR, USA;2. Department of Electrical and Computer Engineering, Portland State University, Portland, OR, USA |
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| Abstract: | AimCentral arterial hemodynamics is associated with cognitive impairment. Reductions in gait speed during walking while performing concurrent tasks known as dual-tasking (DT) or multi-tasking (MT) is thought to reflect the cognitive cost that exceeds neural capacity to share resources. We hypothesized that central vascular function would associate with decrements in gait speed during DT or MT.MethodsGait speed was measured using a motion capture system in 56 women (30–80y) without mild-cognitive impairment. Dual-tasking was considered walking at a fast-pace while balancing a tray. Multi-tasking was the DT condition plus subtracting by serial 7′s. Applanation tonometry was used for measurement of aortic stiffness and central pulse pressure. Doppler-ultrasound was used to measure blood flow velocity and β-stiffness index in the common carotid artery.ResultsThe percent change in gait speed was larger for MT than DT (14.1 ± 11.2 vs. 8.7 ± 9.6%, p < 0.01). Tertiles were formed based on the percent change in gait speed for each condition. No vascular parameters differed across tertiles for DT. In contrast, carotid flow pulsatility (1.85 ± 0.43 vs. 1.47 ± 0.42, p = 0.02) and resistance (0.75 ± 0.07 vs. 0.68 ± 0.07, p = 0.01) indices were higher in women with more decrement (third tertile) as compared to women with less decrement (first tertile) in gait speed during MT after adjusting for age, gait speed, and task error. Carotid pulse pressure and β-stiffness did not contribute to these tertile differences.ConclusionElevated carotid flow pulsatility and resistance are characteristics found in healthy women that show lower cognitive capacity to walk and perform multiple concurrent tasks. |
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| Keywords: | Gait speed Dual-task Walking Carotid artery Vascular function Pulsatility index |
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