Effect of liquid and solid test meals on symptoms and gastric myoelectrical activity in patients with gastroparesis and functional dyspepsia |
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| Authors: | Kenneth L. Koch Mark Van Natta Henry P. Parkman Madhusudan Grover Thomas L. Abell Richard W. McCallum Hossam A. Shaltout Irene Sarosiek Gianrico Farrugia Robert J. Shulman James Tonascia Laura Miriel Frank Hamilton Pankaj J. Pasricha Gastroparesis Clinical Research Consortium |
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| Affiliation: | 1. Section on Gastroenterology, Wake Forest University, Winston-Salem, North Carolina, USA;2. Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA;3. Section of Gastroenterology, Temple University, Philadelphia, Pennsylvania, USA;4. Mayo Clinic Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA;5. Digestive and Liver Health, University of Louisville, Louisville, Kentucky, USA;6. Division of Gastroenterology, Texas Tech University, El Paso, Texas, USA;7. Cardiovascular Sciences Center, Wake Forest University, Winston-Salem, North Carolina, USA;8. Children’s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA;9. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA;10. Center for Neurogastroenterology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA |
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| Abstract: | Background Patients with gastroparesis (GP) and functional dyspepsia (FD) have similar symptoms, but the pathophysiology of postprandial symptoms remains uncertain. Aims To compare symptoms and gastric myoelectrical activity (GMA) after liquid and solid test meals in patients with GP and FD. Methods Patients enrolled in the Gastroparesis Clinical Research Consortium Registry were studied. Clinical characteristics were measured with standard questionnaires. GP was determined by 4-h solid-phase gastric scintigraphy. GMA was measured using electrogastrography before and after ingestion of a water load or nutrient bar on separate days. Symptoms were measured on visual analog scales. GMA responses to the water load for individual patients were also determined. Results 284 patients with GP and 113 with FD were identified who ingested both test meals. Patients with GP and FD had similar maximal tolerated volumes of water [mean (SD) 378 (218) ml vs. 402 (226) ml, p = 0.23] and reported similar intensity of fullness, nausea, bloating, and abdominal discomfort after the test meals. Twenty-six percent and 19% of the patients with GP and FD, respectively, ingested subthreshold (<238 ml) volumes of water (p = 0.15). Gastric dysrhythmias were recorded in 66% of the GP and 65% of the FD patients after the water load. Symptoms and GMA were similar in both groups after ingestion of the nutrient bar. Conclusion The similarity in GMA responses and symptoms after ingestion of solid or liquid test meals suggests GP and FD are closely related gastric neuromuscular disorders. |
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| Keywords: | functional dyspepsia gastric dysrhythmias gastroparesis nutrient bar meal postprandial distress syndrome water load satiety test |
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