Circadian rhythms and the liver |
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Authors: | Rodolfo Costa Chiara Mangini Esther D. Domenie Lisa Zarantonello Sara Montagnese |
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Affiliation: | 1. Institute of Neuroscience, National Research Council (CNR), Padova, Italy;2. Department of Medicine, University of Padova, Padova, Italy;3. Chronobiology Section, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK |
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Abstract: | This narrative review briefly describes the mammalian circadian timing system, the specific features of the liver clock, also by comparison with other peripheral clocks, the role of the liver clock in the preparation of food intake, and its relationship with energy metabolism. It then goes on to provide a chronobiological perspective of the pathophysiology and management of several types of liver disease, with a particular focus on metabolic-associated fatty liver disease (MAFLD), decompensated cirrhosis and liver transplantation. Finally, it provides some insight into the potential contribution of circadian principles and circadian hygiene practices in preventing MAFLD, improving the prognosis of advanced liver disease and modulating liver transplantation outcomes. |
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Keywords: | decompensated cirrhosis liver clock liver transplantation MAFLD mammalian circadian timing system metabolism |
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