Affiliation: | 1. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;2. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Division for Health Service Promotion, The 3. University of Tokyo, Tokyo, Japan;4. Division for Health Service Promotion, The 5. Department of Infection Control and Prevention, Graduate School of Medicine, The 6. Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan;7. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Infection Control and Prevention, Graduate School of Medicine, The 8. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Gastroenterology, Kanto Central Hospital, Tokyo, Japan |
Abstract: | Aim Differential metabolic risk factors of nonalcoholic fatty liver disease (NAFLD) in nonobese male adolescents were analyzed examining relationships between NAFLD and clinical parameters of metabolic syndrome, including exercise and soft drink consumption, in male adolescents. Methods In total, 134 male university students (nonobese, n = 78; obese, n = 56) who underwent the first-year health checkup were divided into the NAFLD and non-NAFLD groups based on abdominal ultrasonography (AUS) findings. Relationships between NAFLD and metabolic parameters, including body mass index (BMI) and AUS score, were examined in nonobese students. Results Metabolic factors associated with hypertension, abdominal fat, liver damage, dyslipidemia, and impaired glucose tolerance were significantly less common in nonobese students than in obese students. The aforementioned factors and soft drink consumption were significantly more common in the NAFLD group than in the non-NAFLD group. The univariate and multivariate analyses of nonobese students showed that the triglyceride level (odds ratio [OR], 1.06; 95% confidence interval [CI], 1.01–1.10, p = 0.001) was higher and soft drink consumption (OR, 36.8; 95% CI, 3.69–368, p < 0.001) was more common in the NAFLD group than the non-NAFLD group. Conclusions Triglyceride level and soft drink consumption could aid in the detection of NAFLD in nonobese male adolescents. Our findings could provide useful information related to NAFLD and metabolic syndrome in nonobese adolescents. |